Activation of mitogen-activated protein kinases by 5,6-dimethylxanthenone-4-acetic acid (DMXAA) plays an important role in macrophage stimulation期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Activation of mitogen-activated protein kinases by 5,6-dimethylxanthenone-4-acetic acid (DMXAA) plays an important role in macrophage stimulation

Authors:	Sun Jing Wang Liang-Chuan S Fridlender Zvi G Kapoor Veena Cheng Guanjun Ching Lai-Ming Albelda Steven M

Affiliation:	^aThoracic Oncology Research Laboratory, University of Pennsylvania School of Medicine, 1016B ARC, 3615 Civic Center Boulevard, Philadelphia, PA 19104-4318, United States;^bAuckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand

Abstract:

Keywords:	Abbreviations: ARE, adenylate/uridylate-rich elements DMXAA, 5,6-dimethylxanthenone-4-acetic acid ELISA, enzyme-linked immunosorbent assay ERK, extracellular signal-regulated kinase GAPDH, glyceraldehyde 3-phosphate dehydrogenase IFN, interferon IFNAR, interferon alpha receptor IL-6, interleukin 6 IP-10, interferon gamma-induced protein 10 kDa JNK, c-Jun N-terminal kinase LPS, lipopolysaccharide MAPK, mitogen-activated protein kinase MCP-1, monocyte chemotactic protein-1 MK-2, MAP kinase activated kinase-2 NF-κB, nuclear factor kappa-light-chain-enhancer of activated B cells NO, nitric oxide NOD, nucleotide oligomerization domain PCR, polymerase chain reaction RANTES, regulated upon Activation, Normal T-cell Expressed, and Secreted or CCL5 RIP2, receptor-interacting protein 2 or RICK TBK&ndash IRF3, TANK-binding kinase-interferon regulatory factor 3 TBP, TATA-binding protein TLR, toll-like receptor TNF-α, tumor necrosis factor-alpha TTP, tristetraprolin 3&prime -UTR, 3&prime -untranslated region
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