A controlled magnetic resonance imaging study of corpus callosum thickness in schizophrenia |
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| Authors: | H A Nasrallah N C Andreasen J A Coffman S C Olson V D Dunn J C Ehrhardt S M Chapman |
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| Affiliation: | 1. From the Department of Psychiatry, Ohio State University, Columbus, OH USA;2. the Department of Psychiatry University of Iowa, Iowa City, IA USA;3. the Department of Radiology, University of Iowa, Iowa City, IA USA;1. Department of Electronic Science, Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance, Xiamen University, Xiamen, China;2. Department of Communication Engineering, Xiamen University, Xiamen, China;1. Dan F. Smith Department of Chemical Engineering, Lamar University, Beaumont, TX 77710, USA;2. Department of Computer Science, Lamar University, Beaumont, TX 77710, USA;1. Department of Chemistry, Federal University of Lavras, P.O. Box 3037, 37200-000 Lavras, MG, Brazil;2. Department of Chemical and Petroleum Engineering (UFF), Rua Passo da Pátria, 156, Niterói, RJ, Brazil;3. Center for Basic and Applied Research, Faculty of Informatics and Management, University of Hradec Kralove, Hradec Kralove, Czech Republic;1. Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States;2. Department of Electrical Engineering, Technical University of Denmark, Kgs. Lyngby, Denmark |
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| Abstract: | Two previous postmortem studies reported an increased thickness of the corpus callosum in schizophrenic patients compared to psychiatric controls. We report an in vivo study of the corpus callosum in schizophrenic patients (n = 38) and healthy controls (n = 41) using magnetic resonance (MR) brain imaging. A significant increase in mean callosal thickness was found in the middle and anterior, but not the posterior, parts of the callosal body. However, when the patients and controls were compared by gender and handedness, schizophrenic men were found not to differ from control men in callosal thickness, regardless of handedness, whereas schizophrenic women were found to have a highly significant increase in callosal middle and anterior thickness compared to control women. The data suggest that increased callosal thickness in schizophrenia is gender related, a factor that is not considered by postmortem studies. The implications of increased callosal dimensions in female schizophrenics are discussed. |
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