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| 沙眼衣原体临床株基因分型及体外药敏试验结果分析 | |
| 引用本文： | 杨丽娜,江勇,刘全忠. 沙眼衣原体临床株基因分型及体外药敏试验结果分析[J]. 山东医药, 2011, 51(39): 1-3 |
| 作者姓名： | 杨丽娜 江勇 刘全忠 |
| 作者单位： | 1. 天津医科大学第二医院,天津,300211 2. 天津医科大学总医院 |
| 基金项目： | 国家自然科学基金资助项目(30872285) |
| 摘 要： | 目的分析沙眼衣原体（Ct）临床株的基因型分布及其对常用抗菌药物的敏感性;进一步提高泌尿生殖道Ct感染的治疗水平。方法采用聚合酶链反应和限制性内切酶片段长度多态性分析方法对52株Ct行基因分型;测定9种抗菌药物对其的最低抑菌浓度（MIC）。结果 52株Ct中E型49株、G型2株、J型1株。9种抗菌药物对Ct的MIC以红霉素最高,克拉霉素最低;共发现13株红霉素耐药株,未发现对其他药物的耐药株。结论天津地区Ct感染以E型为主,对克拉霉素较为敏感;已发现对红霉素耐药的Ct,应引起临床注意。 |
| 关 键 词： | 沙眼衣原体 基因型 药敏试验 |
Genotyping of Chlamydia trachomatis clinical isolates and analysis of drug sensitive test in vitro |
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| YANG Li-na,JIANG Yong,LIU Quan-zhong. Genotyping of Chlamydia trachomatis clinical isolates and analysis of drug sensitive test in vitro[J]. Shandong Medical Journal, 2011, 51(39): 1-3 | |
| Authors: | YANG Li-na JIANG Yong LIU Quan-zhong |
| Affiliation: | YANG Li-na1,JIANG Yong,LIU Quan-zhong (1 The Second Hospital of Tianjin Medical College,Tianjin 300211,P.R.China) |
| Abstract: | Objective To assess the genotyping distribution of Chlamydia trachomatis(Ct) clinical isolates and its susceptibility to common antimicrobial agents;to improve the treatment level of urogenitaltract infection.Methods Polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP)was performed to determine the genotype of 52 Ct;the MICs of 9 antimicrobial agents to Ct were determined.Results There were 49 strains of E type,2 strains of G type,and 1 strain of J type.The highest MIC of 9 antimicro... |
| Keywords: | Clamydia trachomatis genotypes drug sensitive test |
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