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| 环氧合酶2与胃癌分化程度关系的研究 | |
| 引用本文： | 谷兰,刘桂琴,洪声明,王梅先,吴烨秋. 环氧合酶2与胃癌分化程度关系的研究[J]. 中国医科大学学报, 2004, 33(2): 161-162 |
| 作者姓名： | 谷兰 刘桂琴 洪声明 王梅先 吴烨秋 |
| 作者单位： | 1. 中国医科大学附属第二医院消化内科,辽宁,沈阳,110004 2. 中国医科大学附属第二医院基础医学院病理学教研室,辽宁,沈阳,110004 3. 中国医科大学附属第一医院胃癌研究室,辽宁,沈阳,110004 |
| 摘 要： | 目的:观察环氧合酶2(COX-2)在胃癌组织中的表达与其临床病理特征的关系.方法:将82例胃癌组织切片分别进行HE和免疫组化染色,用X2检验方法分析.结果:COX-2主要存在于胃癌细胞的胞浆中,胃癌组织中表达率87.80%,过表达率65.28%.结论:胃癌组织中COX-2的过表达率与胃癌细胞的分化程度明显相关. |
| 关 键 词： | 环氧合酶 胃腺癌 免疫组织化学 |
| 文章编号： | 0258-4646(2004)02-0161-02 |
| 修稿时间： | 2003-01-07 |
Cyclooxygenase-2 protein overexpression in human gastric carcinoma relevance to tumor differentiation |
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| GU Lan,LIU Gui-qin,HONG Sheng-ming,WANG Mei-xian,WU Ye-qiu. Cyclooxygenase-2 protein overexpression in human gastric carcinoma relevance to tumor differentiation[J]. Journal of China Medical University, 2004, 33(2): 161-162 | |
| Authors: | GU Lan LIU Gui-qin HONG Sheng-ming WANG Mei-xian WU Ye-qiu |
| Affiliation: | GU Lan1,LIU Gui-qin1,HONG Sheng-ming2,WANG Mei-xian3,WU Ye-qiu3 |
| Abstract: | Objective: To investigate cyclooxygenase-2(COX-2) expression in gastric cancer and its relationship with clinical-pathological features. Methods:Serial tissue samples were stained with HE for routine pathological examination and stained with COX-2 polyclonal antibody for immunohistochemical examination. Results:We found COX-2 protein mainly in cytoplasm of gastric cancer cells. The rates of COX-2 expression and overexpression were 87.80 percent and 65.28 percent respectively. Conclusion:The overexpression of COX-2 protein is related with differentiation of cancer cells. |
| Keywords: | cyclooxygenase gastric adenocarcinoma immunohistochemistry |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |