经阴道和腹腔镜行良性卵巢肿瘤切除术对患者体液免疫功能的影响

目的观察采用经阴道和腹腔镜不同手术方式切除卵巢良性肿瘤时患者体液免疫的影响。方法120例卵巢良性肿瘤患者随机分为经阴道手术组60例和经腹腔镜手术组60例行卵巢良性肿瘤切除，所有患者分别于术前及术后12小时取周围静脉自凝血2ml，用免疫比浊方法测定IgG、IgA、IgM和CRP。结果①经阴道手术组术后IgG、IgA和IgM无明显变化（P〉0．05）；腹腔镜组术后IgG、IgA和IgM明显降低（P〈0．01）；两组阃术后IgG、IgA和IgM比较，差异有显著性（P〈0．01）。②两组术后周围血CRP与术前比较，差异均有显著性（P〈0．01）；组间比较差异亦有显著性（P〈0．01）。结论经阴道手术对患者体液免疫功能几乎没有影响，而腹腔镜手术后患者体液免疫功能受到明显抑制。这两种方式手术后机体血清CRP均明显升高，其中腹腔镜术后血清CRP升高幅度大。

Influence of transvaginal and translaparoscopic benign ovarian tumorectomy on humoral immunity

Objective To investigate the influence of benign ovarian tumorectomy with different surgical routes on humoral immunity. Methods 120 cases of benign ovarian tumor that Were confirmed by pathological findings after surgery were randomized into two groups：60 cases underwent transvaginal benign ovarian tumorectomy and other 60 cases, translaparoscopic tumorectomy. The IgG,IgA,IgM and CRP before and 12 hours after surgery were detected in all eases. Results There were no significant changes in IgG,IgA,IgM in patients undergoing transvaginal tumorectomy before and after surgery, but the values were obviously decreased in those undergoing translaparoscopic tumorectomy（P〈0.01）. There was significant deference in IgG,IgA,IgM between two groups after surgery. There was significant deference in CRP before and after surgery in both groups（P〈0. 01）, so was between two groups after surgery（P〈0. 01）. Conclusion Ttransvaginal benign ovarian tumoreetomy can hardly affect humoral immunity, whereas translaparoscopic benign ovarian tumorectomy obviously inhibits humoral immunity. Both the surgical interventions will elevate CRP levels, of which translaparoseopie ways is more evident.