载脂蛋白B基因多态性与胆固醇结石病关系的研究

目的 探讨载脂蛋白Ｂ（ａｐｏＢ）基因多态位点Ｉｎｓ／Ｄｅｌ，ＸｂａＩ基因多态与胆固醇结石病的关系。方法 应用聚合酶链反应法和限制性片段长度多肽法，观察这两个多态位点１０１例胆固醇结石患者和５０例对照者的分布，结果 结石ＸｂａＩ多态位点的Ｘ＾＋等位基因频率显著高于对照组（Ｘ＾２＝４．０５，Ｐ〈０．０５），Ｘ＾＋Ｘ＾－基因型分布也显著高于对照组（Ｘ＾２＝４．５０，Ｐ〈０．０５），结石组Ｉｎｓ／Ｄｅｌ多

Association of polymorphisms of apolipoprotein B gene with cholesterol gallstone disease

Objective To investigate the association between the apolipoprotein B (apoB) gene po1ymorphic sites Ins/De1 and Xbal, and cholesterol gallstone disease Methods The two polymorphic sites of apoB gene were examed in 101 cholesterol gallstone patients and 50 controls by polymerase chain reaction and restriction fragment length polymorphism methods. Results For Xbal polymorphic site, the frequency of the rare allele X and the distribution of X X - genotype were significantly higher in the patient group than in the control group ( P < 0 05) For Ins/Del polymorphic site, no significant difference was found in allele frequency and genotype distribution between the patient group and the control group Conclusions Xba1 polymorphism of apoB gene may be associated with cholesterol gallstone disease The association, however, is not present for Ins/De1 polymorphism of apoB gene with cholesterolg allstone disease