Chorioallantoic membrane capillary bed: A useful target for studying angiogenesis and anti-angiogenesis in vivo |
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| Authors: | Domenico Ribatti Beatrice Nico Angelo Vacca Luisa Roncali Peter H. Burri Valentin Djonov |
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| Affiliation: | 1. Department of Human Anatomy and Histology, University of Bari Medical School, Piazza Giulio Cesare, Bari, Italy;2. Department of Biomedical Sciences and Human Oncology, University of Bari Medical School, Piazza Giulio Cesare, Bari, Italy;3. Institute of Human Anatomy, University of Berne Medical School, Berne, Switzerland |
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| Abstract: | The chick embryo chorioallantoic membrane (CAM) is an extraembryonic membrane that is commonly used in vivo to study both angiogenesis and anti-angiogenesis. This review 1) summarizes the current knowledge about the structure of the CAM's capillary bed; 2) discusses the controversy about the existence of a single blood sinus or a capillary plexus underlying the chorionic epithelium; 3) describes a new model of the CAM vascular growth, namely the intussusceptive mode; 4) reports findings regarding the role played by endogenous fibroblast growth factor-2 in CAM vascularization; and 5) addresses the use and limitations of the CAM as a model for studying angiogenesis and anti-angiogenesis. Anat Rec 264:317–324, 2001. © 2001 Wiley-Liss, Inc. |
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| Keywords: | angiogenesis anti-angiogenesis chorioallantoic membrane fibroblast growth factor-2 intussusceptive growth |
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