六淫致病对儿童哮喘的影响及冷热哮证微观指标的观察

[目的]观察六淫致病对儿童哮喘的影响及冷热哮证的微量指标变化.[方法]采用Logistic回归分析六淫的作用,测定冷热哮证患儿血清抗体IgE、嗜酸性细胞计数(EOS)、补体C3、C反应蛋白(CRP)4项微观指标的水平变化.[结果]风、寒、湿及风寒和寒湿夹杂是哮喘的危险因素;冷哮患者的血清抗体IgE、EOS水平高于热哮患者,热哮患者的血清补体C3、CRP水平高于冷哮患者(均P<0.05).[结论]六淫致病对不同的疾病有不同的影响,冷热哮证的中医辨证分型有其不同的现代病理生理学基础.

Influence of Six Exogenous Pathogenic Factors on Asthma in Children and Observation on Microscopic Indexes in Cold-and Heat-Type Asthma

To investigate the influence of six exogenous pathogenic factors on asthma in children and to observe the changes of microscopic indexes in cold- and heat-type asthma. Logistic regression analysis was applied to analyze the influence of six exogenous pathogenic factors and the changes of serum level of IgE, eosinophil (EOS) counting, contents of third component of complement (C3) and C-reactive protein (CRP) were observed. The exogenous factors of wind, cold, damp, wind-cold mixture and cold-damp mixture were the risky factors of asthma. Serum levels of IgE and EOS were higher in cold-type asthma and serum contents of C3 and CRP were higher in heat-type asthma (P<0.05).[Conclusion]Six exogenous pathogenic factors have certain influence on asthma in children,showing that the modern pathophysiological basis is different in cold- and heat-type asthma.