炎症与心房颤动发生及转归的关系

血管紧张素Ⅱ、基质金属蛋白酶9、缺氧诱导因子1α、TLR2作为免疫炎性因子在房颤患者体内有不同程度的升高,反映炎性反应在房颤的发生与维持中发挥重要作用。相关药物(如他汀类药物、血管紧张素转换酶抑制剂或血管紧张素受体拮抗剂)、激素的抗炎作用对房颤的发生和维持有一定的影响。现就炎症与房颤发生与转归的关系进行综述。

The Relationship between Inflammation and the Occurrence and Clinical Outcome of Atrial Fibrillation

AngiotensinⅡ,matrix metalloproteinase-9,hypoxia-inducible factor-1α,Toll-like receptor-2 as immune inflammation factors rise in different degree in the patients with atrial fibrillation.It reflects that inflammatory reaction plays an important role in the occurrence and maintainance of atrial fibrillation.Related drugs such as statins,angiotensin converting enzyme inhibitors or angiotensin receptor antagonist,hormone which anti-inflammatory effects have certain effects in the occurrence and maintainance of atrial fibrillation. Here is to review the relationship between inflammation and the occurrence and clinical outcome of atrial fibrillation.