miRNA与肿瘤耐药关系的研究进展

微小RNA(miRNA)参与生命过程中一系列的重要过程,其异常表达与肿瘤的发生、发展密切相关。不同miRNA可呈现出癌基因或抑癌基因样功能,并有一定的组织特异性。一些miRNA以肿瘤细胞中对药物敏感的相关基因为靶点,以此提高抗肿瘤药物的疗效。天然提取物(如大豆异黄酮3、3,'-二吲哚甲烷、儿茶素酸酯等)可改变miRNA表达谱,使肿瘤细胞对传统治疗方法的敏感性增加,提示以特定的miRNA为靶点,通过克服耐药性开辟新的途径,可以改进肿瘤治疗的结果。

Progress in the Research of miRNA and Cancer Drug Resistance

MiRNA expression is correlated with the development and progression of cancers.Different miRNAs may act as oncogenes or antioncogenes,and all of them have tissue specificity.Moreover,some miRNAs could target genes related to drug sensitivity,resulting in the altered sensitivity of cancer cells to anti-cancer drugs.Recent studies have shown that natural agents including isoflavone,3,3′-diindolylmethane,and(-)-epigallocatechin-3-gallate altered miRNA expression profiles,leading to an increased sensitivity of cancer cells to conventional therapeutics.These results suggest that specific targeting of miRNAs by different approaches could open new avenues for cancer treatment through overcoming drug resistance and thereby improve the outcome of cancer therapy.