颈动脉粥样硬化斑块形成的相关因素分析

目的探讨颈动脉斑块形成的主要相关因素,以指导临床进行缺血性脑卒中的预防。方法选择2010年12月至2011年3月期间在广西医科大学第四附属医院住院的患者61例,检测所有患者血三酰甘油、总胆固醇、低密度脂蛋白、血糖、单核细胞计数、超敏C反应蛋白、肌酐、β2微球蛋白水平;记录患者既往是否有高血压病、糖尿病、吸烟史。采用彩色多普勒超声仪观察颈动脉管壁内膜中层厚度。结果两组间单因素比较显示斑块组年龄、高血压病发生率、糖代谢异常发生率、超敏C反应蛋白及吸烟水平高于非斑块组;两组间性别、总胆固醇、三酰甘油、低密度脂蛋白、单核细胞计数、肌酐、β2微球蛋白水平比较差异无统计学意义。Logistic回归分析结果显示年龄、收缩压及吸烟进入回归方程,并有统计学意义。结论在本研究中发现年龄、收缩压及吸烟是颈动脉斑块形成的独立危险因素。

The Study on the Factors of the Formation of Carotid Atherosclerotic Plaque

Objective To investigate the major factors of the formation of carotid atheroselerotie plaque so as to prevent cerebral arterial thrombosis. Methods A total of 61 inpatients admitted to Fourth Affiliated Hospital of Guangxi Medical University from December 2010 to March 2011 were included. They were measured the level of＇some possible risk fators including TG, TC, LDL, blood sugar, monocyte count, supersensitivity C reactive protein, ereatinine, 132 microglabulin ; the history of past illness including hypertensive disease, diabetes mellitus and smoking were recorded. The diaerisis of the formation of carotid atheroselerotie plaque was done according to the color Doppler to investigate layer thickness of endomembrane along the line feed of arteria earotis eommunis from lengthways and athwartships. Results The mean age, incidences of hypertension, abnormal glycome- tabolism, supersensitivity C reactive protein and smokings were higher in patients with carotid plaques than in patients without carotid plaques by single-factor analysis. No significant difference of sex,cholesterol total,mean triglyceride, LDL, monocyte count, mean ereatinine and 132 microglobulin. Logistic multi-factor regression analysis showed that age, systolic pressure and smoking were involved in the regression equation statistically. Conclusion In this study, age, systolic pressure and smoking were discovered to be independent risk factors for carotid atherosclerotie plaque.