冠心病与巨细胞病毒初期感染的相关性研究

目的探讨人类巨细胞病毒初期感染与冠心病发生发展的关系。方法用捕获ELISA法检测血清HCMV—IgM，酶法检测血脂4项，免疫比浊法检测C-反应蛋白（CRP），并进行比较。结果冠心病组（61例）、健康对照组（44例）和其他疾病组（48例）的HCMV—IgM阳性率分别为8．20％、2．27％和4．17％，冠心病组与对照组之间无统计学差异（P〉0．05）；冠心病组血脂4项和CRP均高于健康对照组，有统计学差异（P〈0．05）。结论尚不能认为冠心病与巨细胞病毒初期感染有关。

Correlation between Coronary Artery disease and HCMV Incipient ilnfection

Objective To investigate the correlation between the occurrence and development of coronary artery disease（CAD） and HCMV incipient infection. Methods The levels of HCMV - IgM were detected in serum samples of 61 CAD patients,44 healthy individuals and 48 patients without cardiovascular disease and diabetes mellitus by using enzyme -linked immunosorbent assay（ELISA） ,and four indexes of lipoid and C reactive protein（CRP） were detected in serum at the same time. Results The positive rates of HCMV - IgM in CAD group, heathlthy individuals and control group without cardiovascular disease and diabetes mellitus were 8.20% （ 5/61 ） , 2.27% （ 1/44 ） and 4.17% （2/48）,respectively. There were no significant difference between the CAD group with control group（ x^2 = 1. 970,P = 0. 374）. The level of four indexes of lipoid and C reactive protein （CRP） of CAD group were higher than control group（P 〈 0.05）. Conclusion The present study does not suggest that coronary artery disease is associated with HCMV incipient infection.