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| 番茄红素对大鼠脑缺血再灌注后自由基代谢的影响 | |
| 引用本文： | 毛旭娟,张俊峰,梁建芳,郑绘霞. 番茄红素对大鼠脑缺血再灌注后自由基代谢的影响[J]. 医学研究杂志, 2011, 40(9): 95-97 |
| 作者姓名： | 毛旭娟 张俊峰 梁建芳 郑绘霞 |
| 作者单位： | 山西职工医学院基础部, 太原,030012 |
| 摘 要： | 目的探讨大鼠血清中SOD活力和MDA含量在脑缺血再灌注(CIRP)损伤过程中的变化以及番茄红素干预后的影响。方法采用线栓法制作实验大鼠大脑中动脉缺血再灌注模型(MCAO)。将Wistar大鼠随机分为:假手术组、缺血再灌注组(I/R组)(6h、1天、2天、3天、7天组)和番茄红素(LP组)。运用比色法检测大鼠血清中SOD和MDA。结果假手术组中SOD活力高表达、MDA低表达;I/R组的血清中SOD活力在各时间点均低于假手术组,并且在1天显著降低,2天SOD活力降到最低;MDA含量在6h开始升高,1天明显升高,2天达高峰;LP组从CIRP后血清SOD活力明显高于I/R组,MDA含量明显低于I/R组。结论大鼠血清中的SOD、MDA参与了CIRP损伤,番茄红素对大鼠CIRP后发生的氧化损伤有干预作用。 |
| 关 键 词： | 脑缺血再灌注 超氧化物歧化酶 丙二醛 番茄红素 |
| 收稿时间： | 2011-01-01 |
| 修稿时间： | 2011-06-22 |
Effects of Lycopene on Free Radicals Metabolism in Focal Ischemia Reperfusion Rats |
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| Mao Xujuan,Zhang Junfeng,Liang Jianfang,Zheng Huixia. Effects of Lycopene on Free Radicals Metabolism in Focal Ischemia Reperfusion Rats[J]. Journal of Medical Research, 2011, 40(9): 95-97 | |
| Authors: | Mao Xujuan Zhang Junfeng Liang Jianfang Zheng Huixia |
| Affiliation: | Mao Xujuan,Zhang Junfeng,Liang Jianfang,Zheng Huixia.Shanxi Medical College for Continuing Education,Shanxi 030012,China |
| Abstract: | Objective To investigate the free radical mechanism in brain of rats involved in the injury induced by cerebral ischemia-reperfusion.Methods The middle cerebral artery occlusion(MCAO) was occluded with thread according to modified Zea longa's method.Wistar rats were randomly divided into:sham-operation group(sham),ischemia-reperfusion group(IR) 6h,1day,2days,3days,7days.The content of superoxide dismutase(SOD) and malondialdehyde(MDA) in brain tissues were measured by comparative methods.Results The activit... |
| Keywords: | Cerebral ischemia reperfusion superoxide dismutase Malondialdehyde Lycopene |
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