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| 树突状细胞与妊娠免疫耐受的研究进展 | |
| 引用本文： | 罗蕊丽. 树突状细胞与妊娠免疫耐受的研究进展[J]. 医学综述, 2011, 17(24): 3705-3707 |
| 作者姓名： | 罗蕊丽 |
| 作者单位： | 湖北医药学院附属太和医院妇产科,湖北,十堰,442000 |
| 摘 要： | 正常妊娠胚胎作为半同种移植物之所以能够维持取决于母胎界面免疫耐受的形成,树突状细胞(DCs)具有独特的免疫调节能力,既能诱导抗原特异性免疫反应又能诱导免疫抑制,通过调节妊娠期间母体内Th1/Th2平衡向Th2偏移,有利于受精卵着床和胎儿发育,维持正常妊娠。DCs不同的亚型及成熟度对妊娠免疫耐受的影响也不同。DCs还可与自然杀伤细胞及类固醇激素协同作用,共同维系妊娠免疫耐受状态。 |
| 关 键 词： | 树突状细胞 妊娠 免疫耐受 |
Research Advances on Pregnancy Immunological Tolerance and Dendritic Cells |
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| LUO Rui-li. Research Advances on Pregnancy Immunological Tolerance and Dendritic Cells[J]. Medical Recapitulate, 2011, 17(24): 3705-3707 | |
| Authors: | LUO Rui-li |
| Affiliation: | LUO Rui-li,ZHAO Ya-juan.(Department of Gynaecology and Obstetrics,Affiliated Taihe Hospital of Hubei Medical College,Shiyan 442000,China) |
| Abstract: | The fetal-placental unit is a semi-allograft and immunological recognition of pregnancy,together with the subsequent response of the maternal immune system,is necessary for a successful pregnancy.Dendritic cells(DCs)has special capability in immunological regulation,which can induce antigen special immunological response as well as immunological inhibition.DCs can regulate the balance between Th1 and Th2 slope toward Th2 in matrix during pregnancy,which makes for nidation of fertilized ovum,growth of fetus ... |
| Keywords: | Dendritic cells Pregnancy Immunological tolerance |
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