| 凋亡抑制蛋白XIAP在难治性癫痫大鼠脑内的表达 |
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| 引用本文： | 卜吉梅,沈卫红,何双涛,陈英辉. 凋亡抑制蛋白XIAP在难治性癫痫大鼠脑内的表达[J]. 神经疾病与精神卫生, 2009, 9(6): 488-489,492. DOI: 10.3969/j.issn.1009-6574.2009.06.009 |
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| 作者姓名： | 卜吉梅 沈卫红 何双涛 陈英辉 |
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| 作者单位： | 复旦大学附属金山医院神经内科,200540;复旦大学附属金山医院神经内科,200540;复旦大学附属金山医院神经内科,200540;复旦大学附属金山医院神经内科,200540 |
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| 基金项目： | 上海市自然科学基金,上海市卫生局局级科研项目,金山区科委科技创新基金 |
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| 摘 要： | 目的研究杏仁核电刺激点燃的难治性癫痫大鼠脑内凋亡抑制蛋白XIAP表达的情况。方法建立杏仁核电刺激点燃的难治性癫痫大鼠模型,通过药物筛选用出耐药大鼠和药物敏感大鼠,采用免疫组织化学及western blot的方法,分析比较凋亡抑制蛋白XIAP在耐药组与药物敏感组的表达。结果难治性癫痫大鼠脑内XIAP的表达明显高于药物敏感组。结论癫痫大鼠脑内凋亡抑制蛋白XIAP可能参与了难治性癫痫的耐药机制。
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| 关 键 词： | 癫痫 凋亡 X连锁凋亡抑制蛋白 点燃模型 |
Expression of XIAP in cerebra of rats with medically intractable epilepsy |
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| Affiliation: | BUJi-mei, SHEN Wei-hong, HE Shuang-tao, et al. (Department of Neurology, Jinshan Hospital of Fudan University, Shanghai 200540, China.) |
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| Abstract: | Objective To investigate the expression of XIAP protein in cerebra of rats with medically intractable epilepsy. Methods The model of medically intractable epilepsy was established by kindling of amygdale. The expression of XIAP in cerebra was determined by immunohistochemistry and western blot analysis. Results Compared with the control group, XIAP expression was significantly ele- vated in cerebra specimens of rats with medically intractable epilepsy. Conclusions XIAP expression in cerebra of rats with medically intractable epilepsy may be concerned with drug-resistant mechanism of medically intractable epilepsy. |
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| Keywords: | Epilepsy Apoptosis XIAP Kindling model |
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