早发型重度子痫前期出生早产儿临床相关不良结局的研究

目的 探讨早发型重度子痫前期(ES-PE)对早产儿临床疾病的影响.方法 前瞻性地选择2016年1月-2017年12月在厦门大学附属第一医院分娩的孕周≤34周的活产早产儿为研究对象,按暴露因素孕母有无重度子痫前期(S-PE)分为研究组与对照组,观察早产儿的临床结局,收集相关资料进行临床分析.结果 研究期间共出生≤34周的...

Study on the clinicalpoor outcomes of premature infants born by early-onset severe-preeclampsia

Objective To discuss the impact of early-onset severe-preeclampsia(ES-PE)on the clinical outcomes of premature infants.Methods All the live-birth preterm infants with gestational age≤34 weeks,delivered by women with early-onset severe-preeclampsia in the First Affiliated Hospital of Xiamen University from January 2016 to December 2017,were recruited prospectively in this study.Premature infants were divided into study group and control group according to whether their mother had ES-PE during pregnancy or not.The clinical outcomes of the preterm infants were observed,and the related clinical data were collected for analysis.Results Totally 814 live-birth preterm infants with gestational age≤34 weeks were delivered during this study period,with 107 in study group and 707 in control group.Finally infants who met the follow-up criteria in the study group and control group were 101 and 640 cases,respectively.Compared with control group,the incidence rates of cesarean section,neonatal birth asphyxia,neutropenia,thrombocytopenia,nosocomial infections,feeding intolerance,neonatal respiratory distress syndrome(NRDS)and bronchopulmonary dysplasia(BPD)increased significantly in study group(χ²=68.722,13.073,15.759,14.910,5.221,4.515,8.117,4.192,P<0.05).The average birth weight of the study group was less than that of control group(t=-2.120,P<0.05),while the average hospitalization day of the study group was longer than that of the control group(t=2.862,P<0.05)between the two groups(P>0.05).Conclusion ES-PE affects the birth way and birth weight of preterm infants,increases adverse events rate,hospitalization day in preterm infants,but has no impact on neonatal mortality.