孕期胆固醇和氧化固醇与子代认知发育

胆固醇是大脑发育的重要物质基础,胚胎和胎儿发育需要母体持续转运胆固醇,氧化固醇是胆固醇的代谢物,包括胆固醇合成途径中的前体物和分结代谢过程中产生的代谢产物,可能与大脑功能密切相关。人群研究发现,孕妇血清/浆胆固醇水平与子代多动症、孤独症谱系障碍发病风险有关,但尚需进一步确证。

Correlation of maternal cholesterol and oxysterols during pregnancy with cognitive development in the offspring

Cholesterol, the essential material for brain development, is transported continuously from mothers to fetus during the gestation stage to meet the need of embryonic and fetal development. Oxysterols are oxygenated derivatives of cholesterol or its sterol precursors, and may be closely related to brain function. Population studies have found that the serum/plasma cholesterol levels of pregnant women are correlated with the risk of developing attention-deficit hyperactivity disorder and autism spectrum disorders in offspring, but the research evidence needs to be improved.