| 胞苷环3’,5’一磷酸对正常人淋巴细胞分泌IL-2和IL-2受体表达的抑制作用 |
| |
| 引用本文： | 汪明春,李扬秋,廖继东,姚敏.胞苷环3’,5’一磷酸对正常人淋巴细胞分泌IL-2和IL-2受体表达的抑制作用[J].中国病理生理杂志,1991(5). |
| |
| 作者姓名： | 汪明春 李扬秋 廖继东 姚敏 |
| |
| 作者单位： | 暨南大学医学院血液病研究室
(汪明春，李扬秋，廖继东)，暨南大学医学院血液病研究室(姚敏) |
| |
| 摘 要： | 0.2mM 3’,5’-cCMP不仅能抑制正常人外周血淋巴细胞IL-2的诱生(P<0.01),而且能抑制IL-2受体的表达(P<0.01)。对后者的抑制率为28.9±1.9%。但是在充分IL-2存在的条件下,0.00625mM至0.2mM的3’,5’-cCMP对CTLL-2细胞的增殖有促进作用,这种促进作用在其浓度较低时更为明显。
|
| 关 键 词： | 胞苷环一磷酸 白细胞介素Ⅱ 受体 细胞株 |
The inhibitory effect of 3', 5'-cCMP on the production of human interleukin-2 and the expression of interleukin-2 receptors in vitro |
| |
| Wang Ming-Chun,Li Yang-Qiu,etal.The inhibitory effect of 3', 5'-cCMP on the production of human interleukin-2 and the expression of interleukin-2 receptors in vitro[J].Chinese Journal of Pathophysiology,1991(5). |
| |
| Authors: | Wang Ming-Chun Li Yang-Qiu etal |
| |
| Institution: | Wang Ming-Chun,Li Yang-Qiu,etal Department of Hematology,Medical College,Jinan University,Guangzhou |
| |
| Abstract: | 0.2mM Cytidine 3', 5'-monophosphate (3', 5'-cCMP) inhibits not only the IL-2 production of human peripheral blood mononuclear cells (PBMC) but also the expression of IL-2 receptors. The inhibitory rate on expression of IL-2 receptors is 28.9 1.9%. The proliferation of CTLL-2 cells can be stimulated by 3', 5'-cCMP in concentration from 0.00625mM to 0.2mM when the presence of IL-2 is sufficient. The stimulative effect in low concentration of 3', 5'-cCMP is more obvious than that in high concentration. |
| |
| Keywords: | |
| 本文献已被 CNKI 等数据库收录！ |
|
