厄贝沙坦和依那普利治疗原发性高血压的对比研究

目的对比观察厄贝沙坦与依那普利治疗轻中度原发性高血压的疗效和安全性。方法随机观察厄贝沙坦(41例,150mg～300mg)与依那普利(42例,10～20mg)治疗高血压患者4周和8周的有效率,并分两组进行比较。结果两组治疗第2周后开始平均收缩压、舒张压较治疗前明显降低(P<0.01),在整个治疗期间血压持续平稳下降;厄贝沙坦与依那普利治疗4周降低舒张压总有效率分别为90.2%(37/41)和83.3%(35/42),8周降低舒张压总有效率分别为95.1%(39/41)和90.5%(38/42),两组比较P>0.05。结论厄贝沙坦是一安全、有效、长效,耐受性好,不良反应轻的降压药物。

The Effects of Irbesartan and Enalapril in Patients with Essential Hypertension

Objective To evaluate the efficacy and safety of irbesartan and compare with that of Enalapril in patients from mild to moderate essential hypertension.Methods Patients were randomly assigned to Irbesartan group(n=41),150mg to 300mg/d,or Enalapril group(n=42) 10mg to 20mg/d for 4 and 8 weeks.Results The systolic blood pressure(SBP)and diastolic blood pressure (DBP) decreased significantly in both groups after 2 weeks(P<0.01);BP decreased smoothly and continuously during the entire treatment period;The total efficacy rate for decreased DBP after 4 and 8 weeks treatment of Irbesartan were 90.2 %(37/41) and 95.1%(39/41) respectively,that of Enalapril group were 83.3% (35/42)and 90.5% (38/42) respectively,and the difference between 2 group is significant(P>0.05).Conclusion Irbesartan is a safe,effective,long acting anti-hypertension drug,tolerable and light side-effect.