| Skp2和p27在扁桃体恶性肿瘤中的表达及意义 |
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| 引用本文： | 罗四维,张端莲,任泽梅. Skp2和p27在扁桃体恶性肿瘤中的表达及意义[J]. 实用诊断与治疗杂志, 2009, 23(9) |
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| 作者姓名： | 罗四维 张端莲 任泽梅 |
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| 作者单位： | 1. 郧阳医学院附属人民医院耳鼻咽喉科,湖北省十堰市,442000
2. 武汉大学基础医学院组胚教研室 |
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| 摘 要： | 目的:探讨Skp2与p27在扁桃体恶性肿瘤组织中的表达及与扁桃体恶性肿瘤多项临床病理特征的关系,并探讨二者的相关性。方法:30例手术切除并经病理证实的扁桃体恶性肿瘤标本,同时收集慢性扁桃体炎标本18例。选乳腺癌作为阳性对照。常规HE染色和免疫组织化学S-P法检测各组Skp2和p27的表达,并进行统计学分析。结果:Skp2在扁桃体恶性肿瘤组织中的阳性表达明显高于其在慢性扁桃体炎组织中的阳性表达(P<0.05);p27在扁桃体恶性肿瘤组织中的阳性表达率明显低于其在慢性扁桃体炎组织中的阳性表达率(P<0.01);Skp2、p27的蛋白表达与扁桃体恶性肿瘤的组织类型有关(P<0.05),与年龄、性别、分化程度无关(P>0.05);Skp2、p27在扁桃体恶性组织中的表达呈负相关(P<0.01)。结论:扁桃体恶性肿瘤中Skp2蛋白表达与靶蛋白p27蛋白降解有关,联合检测Skp2、p27蛋白表达可作为判断扁桃体恶性肿瘤生物学行为的指标之一。
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| 关 键 词： | 扁桃体肿瘤 Skp2 p27 免疫组织化学 |
Expression and significance of Skp2 and p27 in tonsil malignant tumor |
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| LUO Siwei,ZHANG Duanlian,REN Zemei. Expression and significance of Skp2 and p27 in tonsil malignant tumor[J]. Journal of Practical Diagnosis and Therapy, 2009, 23(9) |
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| Authors: | LUO Siwei ZHANG Duanlian REN Zemei |
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| Abstract: | Objective To investigate the correlation of Skp2 and p27 expression with the clinical pathological features of tonsil carcinoma,and the correlation between expression of Skp2 and p27 in tonsil carcinoma. Methods Specimens from 30 cases of tonsil cancer and 18 cases of chronic tonsillitis were enrolled in this experiment. All specimens were proved by formalin fixed paraffin-embedded slides with HE staining. The expressions of Skp2 and p27 were determined with immunohistochemical staining. Results The Skp2 la... |
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| Keywords: | Tonsil cancer Skp2 p27 immunohistochemistry |
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