| p53和PCNA联合表达与林州市食管癌患者预后的关系 |
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| 引用本文： | 岳文彬,宋子博,益新娜,王启鸣,王立东,贾云英,牛好敏,张广志,陈社萍. p53和PCNA联合表达与林州市食管癌患者预后的关系[J]. 临床和实验医学杂志, 2002, 1(2): 134-136 |
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| 作者姓名： | 岳文彬 宋子博 益新娜 王启鸣 王立东 贾云英 牛好敏 张广志 陈社萍 |
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| 作者单位： | 河南省濮阳市人民医院,457000;郑州大学医学院癌症研究室,450052;濮阳市人民医院,457000 |
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| 摘 要： | 目的：从分子水平上探索食管癌相关基因的变化。寻找敏感,特异的预后指标。方法：对114例食管癌高发区林州市的食管癌患进行五年随访,采用组织病理学和免疫组织化学等方法检测p53和增殖细胞核抗原（PC－NA）在食管癌组织中的表达状况,用Kaplan-Meire法分析p53和PCNA联合表达与林州市食管癌患预的的关系。结果：p53和PCNA同时高表达的食管癌患生存期小于同时低表达,p53和PCNA联合表达对于判断食管癌预后的意义优于单独以PCNA作为预后指标,结论：单一指标判断预后具有一定的局限性,多因素、多指标综合评价食管癌患的预后可能更好地反映患的实际情况,具有重要的临床指导意义。
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| 关 键 词： | 食管癌 高发区 PCNA p53 预后 |
| 文章编号： | 1671-4695(2002)02-0134-03 |
Combiming expression of p53 and PCNA and its relationship with esophageal cancer prognosis on the patients from the high-incidence area for esophageal cancer in Linzhou,Henan |
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| YUE Wenbin,SONG Zibo,YI Xinna,WANG Qiming,WAHG Lidong Laboratory for Cancer Research,College of Medicine,Zhengzhou University,,China JIA Yunying,NIU Haomin,ZHANG Guangzhi,CHEN Sheping Puyang People Hospital,Puyang,,China. Combiming expression of p53 and PCNA and its relationship with esophageal cancer prognosis on the patients from the high-incidence area for esophageal cancer in Linzhou,Henan[J]. Journal of Clinical and Experimental Medicine, 2002, 1(2): 134-136 |
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| Authors: | YUE Wenbin SONG Zibo YI Xinna WANG Qiming WAHG Lidong Laboratory for Cancer Research College of Medicine Zhengzhou University China JIA Yunying NIU Haomin ZHANG Guangzhi CHEN Sheping Puyang People Hospital Puyang China |
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| Affiliation: | YUE Wenbin,SONG Zibo,YI Xinna,WANG Qiming,WAHG Lidong Laboratory for Cancer Research,College of Medicine,Zhengzhou University,450052,China JIA Yunying,NIU Haomin,ZHANG Guangzhi,CHEN Sheping Puyang People Hospital,Puyang,457000,China |
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| Abstract: | Objectives To further characterize the possible relationship between the molecular changes and esophageal carcinoma prognosis and to elucidate the possible mechanisms of esophageal carcinoma carcinogenesis Methods 114 patients were followed up more than five years, immunostaining (ABC) method was employed to detect the alternation of p53 and PCNA in EC, Kaplan-Meier were used for survival analysis Results Patients in coincidence low-expression group obviously survived longer than those in coincidence high-expression group, and the difference was significant ( P <0 05) Conclusions Esophageal cancer patients with p53 and PCNA coincidence low-expression survived longer than those with coincidence high-expression, indicating that multiple parameters may be better than single parameter in evaluating the prognosis |
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| Keywords: | Esophageal carcinoma High-incidence area PCNA p53 Prognosis |
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