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Imidazoquinoline Toll-like receptor 8 agonists activate human newborn monocytes and dendritic cells through adenosine-refractory and caspase-1-dependent pathways
Authors:Philbin Victoria J  Dowling David J  Gallington Leighanne C  Cortés Guadalupe  Tan Zhen  Suter Eugénie E  Chi Kevin W  Shuckett Ariel  Stoler-Barak Liat  Tomai Mark  Miller Richard L  Mansfield Keith  Levy Ofer
Affiliation:a Department of Medicine, Division of Infectious Diseases, Children's Hospital Boston, Boston, Mass
b Harvard Medical School, Boston, Mass
c 3M Drug Delivery Systems, St Paul, Minn
d 3M Pharmaceuticals, St Paul, Minn
e New England Primate Research Centre, Southborough, Mass
f Shanghai Jiao Tong University, School of Medicine, Shanghai, China
Abstract:
Keywords:Toll-like receptor 8   innate immunity   neonate   newborn   alum   adjuvant   adenosine   IL-1β   caspase-1   inflammasome
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