In vitro Metabolism of Bumetanide |
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| Authors: | Giorgio Grosa Franca Viola Otto Caputo Giuseppe Biglino |
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| Affiliation: | (1) Istituto di chimica farmaceutica applicata Università, di Torino Corso Raffaello 31, 10125 Torino, Italy |
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| Abstract: | ![]()
A new metabolite of the diuretic drug bumetanide, the 4-[(4 -hydroxy)-phenoxy] analog (7), was identified in incubation mixtures of rat liver microsomes. Phenobarbital and clofibrate pretreatment to induce microsomal enzymes changed the relative amounts of the six metabolites formed. Compound 7was the most prevalent metabolite after clofibrate pretreatment. |
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