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Tumor‐associated mutations in O6‐methylguanine DNA‐methyltransferase (MGMT) reduce DNA repair functionality |
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| Authors: | Kristy L. Lamb Yanfeng Liu Kimiko Ishiguro Youngho Kwon Nicolas Paquet Alan C. Sartorelli Patrick Sung Sara Rockwell Joann B. Sweasy |
| Affiliation: | 1. Department of Therapeutic Radiology, Yale University School of Medicine, , New Haven, Connecticut;2. Department of Genetics, Yale University School of Medicine, , New Haven, Connecticut;3. Department of Pharmacology, Yale University School of Medicine, , New Haven, Connecticut;4. Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, , New Haven, Connecticut |
| Abstract: | |
| Keywords: | O(6)‐benzyguanine O(6)‐alkylguanine DNA alkyltransferase MNNG DNA repair O‐(6)‐methylguanine |