注射用氯诺昔康与盐酸吗啡注射液在0.9%氯化钠注射液中的稳定性

目的 考察注射用氯诺昔康与盐酸吗啡注射液在0.9%氯化钠注射液中的稳定性. 方法 在室温(20±1) ℃避光条件下,观察和检测注射用氯诺昔康与盐酸吗啡注射液在0.9%氯化钠注射液中配伍液在72 h内的外观及pH变化,并用反相高效液相色谱法测定氯诺昔康与盐酸吗啡的含量. 结果配伍液72 h内外观、pH及含量均无明显变化. 结论 室温条件下,注射用氯诺昔康与盐酸吗啡注射液在0.9%氯化钠注射液中72 h内稳定.

Stability and Compatibility of Lornoxicam and Morphine Hydrochloride in 0.9% Sodium Chloride Injection

Objective To study the stability and compatibility of lornoxicam and morphine hydrochloride in 0.9% sodium chloride injection.Methods In 0.9% sodium chloride injection,the content change of lornoxicam and morphine hydrochloride was determined by reversed phased high performance liquid chromatogram under room temperature(20±1) ℃ within 72 h,and the appearance of the solution was observed and its pH value was determined.Results No significant differences were found in the content,color and pH value for the mixed solution at different time points within 72 h after mixing at room temperature.Conclusion The mixture of lornoxicam and morphine hydrochloride in 0.9% sodium chloride injection at ambient temperature was stable within 72 h.