| 趋化因子CXCL12及其受体CXCR4介导乳腺癌转移分子机制 |
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| 引用本文： | 李瑞杰,樊青霞. 趋化因子CXCL12及其受体CXCR4介导乳腺癌转移分子机制[J]. 国际肿瘤学杂志, 2009, 36(3). DOI: 10.3760/cma.j.issn.1673-422X.2009.03.014 |
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| 作者姓名： | 李瑞杰 樊青霞 |
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| 作者单位： | 郑州大学第一附属医院肿瘤科,450052;郑州大学第一附属医院肿瘤科,450052 |
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| 摘 要： | 趋化因子CXCL12及其受体CXCR4之间的相互作用在乳腺癌转移中起着枢轴作用.新近研究发现,CXCR4-CXCL12介导的乳腺癌转移与缺氧诱导因子-1(HIF-1)、Her-2、核因子-κB(NFκB)、尿激酶型纤维蛋白酶原激活剂受体(uPAR)等分子密切相关,明确CXCL12-CXCR4介导的乳腺癌转移分子机制,进而逐个阻断上游分子对二者的调控作用,开发出靶点明确、作用特异的抗转移药物将使乳腺癌患者获益.
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| 关 键 词： | 趋化因子 CXC 受体 乳腺肿瘤 |
Molecular mechanisms of breast cancer metastasis mediated by chemokine CXCL12 and it's receptor CXCR4 |
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| Abstract: | The interaction of CXCL12 and CXCR4 has a pivotal role in breast cancer metastasis. Re- cent studies have identified that the metastasis of breast cancer mediated by CXCL-12-CXCR4 is associated with HIF-1、Her-2、NF-κB、and uPAR. We should determine the molecular mechanisms as soon as possible,and then block the function of up- stream molecules, exploit new anti- metastatic drugs. These developments will be translated into significant survival benefits for patients. |
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| Keywords: | CXC |
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