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甘露醇对脑卒中急性肾损伤患者肾功能的影响
引用本文:沈健,智睿,杨素萍. 甘露醇对脑卒中急性肾损伤患者肾功能的影响[J]. 中国现代药物应用, 2009, 3(20): 46-47
作者姓名:沈健  智睿  杨素萍
作者单位:江苏省大丰市人民医院,224100
摘    要:
目的了解甘露醇对脑卒中急性肾损伤(AKI)患者肾功能的影响。方法收集脑卒中AKI患者62例,随机分为甘露醇治疗组(31例),继续使用20%甘露醇125ml静脉滴注,6—8h1次;对照组(31组)不使用甘露醇,测定两组每个患者第2天、第4天、第7天血肌酐值。结果①治疗组第4日血肌酐(109.3±38.9)mmol/L,第7日血肌酐(118.7±46.3)mmol/L,(t=0.87,P〉0.05);②治疗组第4日血肌酐升高值(37.1±26.2)mmol/L,第7日肌酐升高值(45.4±29.8)mmol/L,(t=0.77,P〉0.05)。结论脑卒中AKI患者使用甘露醇(〈50g/d)是相对安全的,不会导致血肌酐明显升高。

关 键 词:脑卒中  急性肾损伤  甘露醇  肾功能

Effect of mannitol on renal function of strock with acute kidney injury
Affiliation:SHEN Jian, ZHI Rui, YANG Su- ping. (Dafeng people' s hospital ,Dafeng 224100, China )
Abstract:
Objective To study the effect of mannitol of stroke with acute kidney injury (AKI). Methods Today 62 stroke with AKI patients were divided into two groups: mannitol treating group(31 cases) and control (31 cases). Set was measured in 2 days, 4 days and 7 days after their stroke. Result (1)The Ser in mannitol group was [ ( 118.7 ± 46. 3 ) mmol/L] after 7 days and [ ( 109. 3 ± 38.9) mmol/L] after( t = 0. 87, P 〉 :0. 05 ) ; (2)Increase if Ser in mannitol group after 7 days [ (45.4 ± 29. 8 ) mmol/L] was not higher than that after 4 days [37.1 ±26. 2) mmol/L] (t = 0.77,P 〉0.05). Conclusion Mannitol (〈50g/d) is safe on treating stroke with AKI.
Keywords:Stroke Acute kidney injury Mainnitol Renal function
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