欧必亭与康泉预防化疗引起恶心呕吐的临床疗效

目的 观察欧必亭（Tropisetron)预防化疗所致恶心呕吐的疗效和不良反应，燕与康泉（Kytril)进行对比研究。方法 采用临床随机自身对照方法，将34例接受联合化疗（19例含顺铂）的患者随机分为AB、BA两组，均接受两个周期相同方案的化疗，AB组第1周期用欧必亭，第2周期用康泉，第2周期用欧必亭。结果 化疗第1天欧必亭组止吐的有效率为97.1%，中位呕吐次数为4.5次。康泉的有效率为94.1%，中位呕吐次数为3交化统计学处理，两组差异无显著性。对迟发性呕吐和融作用也进行了对比，欧必亭和康泉差异亦无显著性。结论 欧必亭为预防化疗所致恶心呕吐的有效药物，其不良反应轻微。

The clinical effect of Tropisetron in the prevention of nausea and vomiting induced by anti-cancer drugs

Objective To compare the efficacy and adverse effects of Tropisetron with Kytril in the prevention of nausea and vomiting induced by anti cancer drugs.Methods In a clinical randomized controlled cross over trial, 34 patients (19 among them treated with regimens containing cisplatin) were randomized into A and B group. In group A, Tropisetron was given in the first cycle and Kytril in the second cycle, while in group B Kytril was given in the first and Tropisetron in the second cycle of the same chemotherapy. Results In the Tropisetron treated group, the response rate was 97.1% with 4.5 episodes of vomiting on the first day of chemotherapy, while that in the Kytril treated patients was 94.1% with 3 episodes of vomiting. There was no statistical difference between the 2 groups. Control of delayed emesis and other adverse reactions were comparable in both arms and there was no notable difference between Tropisetron and Kytril.Conclusion Tropisetron is an effective anti emetic drug to prevent nausea and vomiting caused by anti tumor agents, and its adverse reactions are mild.