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| 北豆根总碱对氢化可的松模型小鼠的免疫调节作用 | |
| 引用本文： | 徐静华 于庆海. 北豆根总碱对氢化可的松模型小鼠的免疫调节作用[J]. 中药药理与临床, 1998, 14(1): 24-25 |
| 作者姓名： | 徐静华 于庆海 |
| 作者单位： | 沈阳药科大学中药药理教研室 |
| 摘 要： | 北豆根总碱２５ｍｇ／ｋｇ、５０ｍｇ／ｋｇｉｐ能显著增强氢化可的松所致免疫功能低下模型小鼠单核巨噬细胞吞噬功能、迟发型超敏反应及血清溶血素的生成；北豆根总碱５０ｍｇ／ｋｇｉｐ能显著增加模型鼠外周血淋巴细胞ＡＮＡＥ阳性百分率，增加脾脏空斑形成细胞溶血能力。提示北豆根总碱对免疫功能低下小鼠有免疫增强作用。 |
| 关 键 词： | 北豆根总碱；氢化可的松；吞噬功能；迟发型超敏反应；溶血素；ANAE染色；空斑形成细胞 |
Immunomodulatory Effects of Total Alkaloid of Menispermum in Hydrocortisone Model Mice |
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| Xu Jinghua,Yu Qinhai. Immunomodulatory Effects of Total Alkaloid of Menispermum in Hydrocortisone Model Mice[J]. Pharmacology and Clinics of Chinese Materia Medica, 1998, 14(1): 24-25 | |
| Authors: | Xu Jinghua Yu Qinhai |
| Abstract: | In present paper,the immunomodulatory effects of Total Alkaloid of Menispermum (TAM) in hydrocortisone model mice were studied.The experimental results showed that TAM ip 25mg/kg,50mg/kg significantly enhanced phagocytosing function of monocyte macrophage system,delayed type hypersensitivity(DTH) reaction and the development of serum hemolysin in mice treated by hydrocortisone.TAM 50mg/kg markedly increased ANAE( ) cell percentage of peripheral blood lymphocytes and the production of spleen plaque forming cell(PFC) in hydrocortisone treated mice.It indicated that TAM had the immunomodulatory effect in hypoimmune mice. |
| Keywords: | Total alkaloid of Menispermum (TAM) hydrocortisone phagocytosis DTH hemolysin ANAE PFC |
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