糖尿病肾病患者空腹血糖及糖化血红蛋白水平控制研究

目的 探讨糖尿病未并发糖尿病肾病患者空腹血糖、糖化血红蛋白水平。方法运用回顾性调查的方法进行糖尿病肾病的资料收集，数据在非条件Logistic回归分析的基础上，利用回归方程对糖尿病肾病患者空腹血糖、糖化血红蛋白控制水平进行研究。结果根据糖尿病肾病发生的不同概率、尿微量白蛋白及血肌酐水平的空腹血糖和糖化血红蛋白阈值，认为空腹血糖6．8mmol／L是预防糖尿病肾病发生的参考值，6．0mmol／L是严格控制糖尿病肾病发生的空腹血糖值；糖化血红蛋白5．9％是预防糖尿病肾病发生的参考值，5．3％是严格控制糖尿病肾病发生的糖化血红蛋白值。结论随着发生糖尿病肾病概率P值的降低及尿微量白蛋白、血肌酐水平的逐渐增高，应对空腹血糖、糖化血红蛋白阈值加以严格控制，并控制在较低的水平。

Study on the Controlling Level of Fasting Blood Gucose and Glucosylated Hemoglobin for Nephropathy in Diabetes Mellitus

Objective To explore the controlling level of fasting blood glucose(FBG) and glucosylated hemoglobin(GH) in order to stop occurrence of nephropathy in diabetic mellitus.Methods Data was collected by retrospective study,analyzed by non-conditional Logistic regression.Then the controlling levels of blood glucose and glucosylated hemoglobin were studied by regression equation.Results It was regarded that under 6.8 mmol/L of FBG and 5.9% of GH,diabetic nephropathy can be prevented;while under 6.0 mmol/L of FBG and 5.3% of GH,the onset of diabetic nephropathy was strictly controlled.Conclusion it is more important to control strictly on the threshold of fasting blood glucose and glucosylated hemoglobin for prevention of diabetic nephropathy.