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5-Fluorouracil induces defects in platelet function |
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| Authors: | Anand Kumar Rajeev Kumar Amitabh Sandilium Jyoti Shukla Satyajit Pradhan |
| Affiliation: | 1. Department of Surgery, Institute of Medical Sciences. Banaras Hindu University, Varanasi 221 005, India;2. Department of Pathology, Institute of Medical Sciences. Banaras Hindu University, Varanasi 221 005, India;3. Department of Radiotherapy and Nuclear Medicine, Institute of Medical Sciences. Banaras Hindu University, Varanasi 221 005, India |
| Abstract: | Platelet factor-3 (PF3) availability and platelet aggregation to ADP (4 μmol/l) and adrenaline (1.2 μmol/1) were evaluated in patients being treated with 5-fluorouracil (5-FU) for gastrointestinal malignancy. It produced a significant reduction in platelet aggregation and platelet factor-3 (PF3) availability (P <0.001) without being associated with thrombocytopenia. The changes in platelet aggregation occurred during the first week of chemotherapy and continued with subsequent courses. This acquired abnormality may be responsible for a haemorrhagic diathesis even without obvious thrombocytopenia. Study of platelet function is important and may be considered to assess the haematological toxicity in patients being treated with systemic 5-FU therapy. |
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