注射用丹参多酚酸联合阿司匹林对急性脑梗死患者神经功能及血清MMP-7和超敏C反应蛋白的影响

目的 探讨注射用丹参多酚酸联合阿司匹林对急性脑梗死患者神经功能及血清基质金属蛋白酶-7（MMP-7）和超敏C反应蛋白（hs-CRP）的影响。方法 选取2017年8月-2018年10月保定市第一中心医院收治的急性脑梗死患者100例为研究对象，采用随机数字表法将患者分为对照组（49例）和观察组（50例）。对照组给予阿司匹林肠溶片，100 mg/次，晨起空腹温水服用，1次/d。观察组在对照组的基础上静脉滴注丹参多酚酸，0.13 g加入0.9%的氯化钠溶液250 mL。两组均持续治疗14 d。比较两组患者治疗前后的美国国立卫生研究院卒中量表（NIHSS）评分、基质金属蛋白酶-7（MMP-7）及超敏C反应蛋白（hs-CRP）水平。结果 治疗后，两组NIHSS评分均明显降低，同组治疗前后比较差异具有统计学意义（P<0.05）；且观察组NIHSS评分显著低于对照组（P<0.05）。治疗后，两组患者血清MMP-7和hs-CRP水平均显著降低，同组治疗前后比较差异具有统计学意义（P<0.05）；且观察组MMP-7和hs-CRP水平显著低于对照组（P<0.05）。结论 在常规脑梗死治疗基础加用注射用丹参多酚酸应用于急性脑梗死患者，可有效降低其血清MMP-7和hs-CRP水平，显著提高脑梗死患者的NIHSS评分，且安全性好，具有一定的临床推广应用价值。

Effects of Salvianolic Acids for Injection combined with aspirin on nerve function and serum MMP-7 and hs-CRP in patients with acute cerebral infarction

Objective To investigate the effects of Salvianolic Acids for Injection combined with aspirin on nerve function and serum MMP-7 and hs-CRP in patients with acute cerebral infarction. Methods A total of 100 patients with acute cerebral infarction admitted to Baoding NO.1 Central Hospital from August 2017 to October 2018 were selected as the study objects, and the patients were divided into the control group (49 cases) and the observation group (50 cases) using the random number table method. Patients in the control group were given Aspirin Enteric-coated Tablets at 100 mg/time, once daily. Patients in the observation group were iv administered with Salvianolic Acids for Injection on the basis of the control group, 0.13 g was added to 0.9% sodium chloride solution 250 mL. Both groups received continuous treatment for 14 d. After treatment, the NIHSS score, and the levels of MMP-7 and hs-CRP before and after treatment were compared in two groups. Results After treatment, NIHSS scores in two groups was significantly decreased, and the difference before and after treatment in the same group was statistically significant (P<0.05). And the NIHSS score in the observation group was significantly lower than that in the control group (P<0.05). After treatment, the serum levels of MMP-7 and hs-CRP in two groups were significantly reduced, and the difference before and after treatment in the same group was statistically significant (P<0.05). And the levels of MMP-7 and hs-CRP in the observation group were significantly lower than those in the control group (P<0.05). Conclusion In this study, the application of Salvianolic Acids for Injection on the basis of conventional treatment of cerebral infarction in patients with acute cerebral infarction can effectively reduce the serum MMP-7 and hs-CRP levels, significantly improve the NIHSS score of patients with cerebral infarction, and the safety is good, with certain clinical application value.