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| 基质金属蛋白酶-9在心血管疾病中的研究进展 | |
| 引用本文： | 张美燕,郑兴. 基质金属蛋白酶-9在心血管疾病中的研究进展[J]. 心血管病学进展, 2007, 28(1): 88-91 |
| 作者姓名： | 张美燕 郑兴 |
| 作者单位： | 上海第二军医大学附属长海医院心内科,上海,200433 |
| 摘 要： | 基质金属蛋白酶-9(MMP-9)又称明胶酶B,在病理情况下潜在型MMP-9被激活,参与许多心血管疾病的发生发展过程,如动脉粥样硬化斑块的形成、破裂,缺血再灌注损伤、心肌梗死后心室重构、充血性心力衰竭进展、心房颤动的发生及维持等。MMP-9/R279Q基因多态现象与稳定型心绞痛患者心血管事件的发生相关并且血浆MMP-9可以作为冠心病患者发生心血管病死亡的预测因子。 |
| 关 键 词： | 基质金属蛋白酶9 急性冠脉综合征 心室重构 心力衰竭 心房颤动 |
| 文章编号： | 1004-3934(2007)01-0088-04 |
| 修稿时间： | 2006-03-16 |
Progression of Matrix Metalloproteases-9 in Cardiovascular Disease |
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| ZHANG Mei-yan,ZHENG Xing. Progression of Matrix Metalloproteases-9 in Cardiovascular Disease[J]. Advances in Cardiovascular Diseases, 2007, 28(1): 88-91 | |
| Authors: | ZHANG Mei-yan ZHENG Xing |
| Affiliation: | Department of Cardiology, Changhai Hospital of The Second Military Medical University, Shanghai 200433, China |
| Abstract: | Matrix metalloproteases-9(MMP-9), also known as gelatinase B. Pro-MMP-9, can be activated in pathological conditions, which is associated with atherosclerotic arterial remodelling, vulnerable plaque development, ischemia-reperfusion injury, cardiac remodelling after acute myocardial infarction, progression of heart failure, and the generation and maintenance of atrial fibrillation. The MMP-9/R279Q polymorphism was shown to be related to future cardiovascular event in patients with stable angina. Plasma MMP-9 concentration was identified as a novel predictor of cardiovascular mortality in patients with coronary artery disease. |
| Keywords: | matrix metalloproteinase-9 acute coronary syndrome ventricular remodeling heart failure atrial fibrillation |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |