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| 多不饱和脂肪酸对金黄地鼠血脂和肝LDL受体的影响 | |
| 引用本文： | 刘传聚,王明运. 多不饱和脂肪酸对金黄地鼠血脂和肝LDL受体的影响[J]. 山东大学学报(医学版), 1993, 0(3) |
| 作者姓名： | 刘传聚 王明运 |
| 作者单位： | 山东医科大学生物化学教研室，山东医科大学生物化学教研室 山东大学生物化学教研室 |
| 摘 要： | 研究了多不饱和脂肪酸对金黄地鼠血脂和肝LDL受体的影响,以探讨多不饱和脂肪酸降低血清脂质的机制。将雄性金黄地鼠30只随机分为对照组和多不饱和脂肪酸组,前者喂基础饲料加0.12%胆固醇,后者再加喂20%的玉米油,5周后测血脂和肝脏LDL受体。结果表明,与对照组相比,多不饱和脂肪酸组血清TC,TG,LDL-C,VLDL-C均明显下降,而HDL-C则明显升高。体外实验发现,多不饱和脂肪酸组金黄地鼠肝匀浆与~(125)I-LDL特异结合位点显著高于对照组,而~(125)I-LDL与两组动物肝匀浆结合的亲和力无明显差别,提示多不饱和脂肪酸降低血脂与肝LDL受体增加密切相关。 |
| 关 键 词： | 脂肪酸类 不饱和 受体 肝 脂蛋白类 金黄地鼠 |
THE EFFECT OF POLYUNSATURATED FATTY ACID ON SERUM LIPIDS AND HEPATIC LDL RECEPTOR IN GOLDEN HAMSTERS |
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| Liu Chuanju,Wang Mingyun. THE EFFECT OF POLYUNSATURATED FATTY ACID ON SERUM LIPIDS AND HEPATIC LDL RECEPTOR IN GOLDEN HAMSTERS[J]. Journal of Shandong University:Health Sciences, 1993, 0(3) | |
| Authors: | Liu Chuanju Wang Mingyun |
| Abstract: | The purpose was to study the effect of dietary polyunsaturatedfats on serum lipids and LDL receptor,30 male Golden hamsters weredivided into 2 groups,the control and the treatment group.The hamstersin the control group were fed with ordinary diets plus cholesterol(0.12%),the hamsters in the treatment group were fed with ordinary diets,cholesterol(0.12%)plus corn oil(20%).All animals were fed for 5 weeks,The results indicated as follows:the serum TC,TG,LDL-C,VLDL-Cwere decreased very significantly in treatment group(P<0.01),whileHDL-C was increased significantly(P<0.05),kd of ~(125)I-LDL bindinghepatic LDL receptor in two groups has no obvious difference,while thenumber of hepatic LDL receptor was increased significantly in the treatmentgroup(P<0.01).The result of the present study suggests that lipid-loweringeffect of polyunsaturated fatty acid is intimately associated with the eleva-tion of hepatic LDL receptors. |
| Keywords: | Fatty acids unsaturated Receptos LDL Liver Lipoproteins Golden hamsters |
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