接触蛋白-1在原发性肺鳞状细胞癌组织中的表达及临床意义

目的探讨神经细胞粘附分子-接触蛋白-1(contactin-1, CNTN-1)在原发性肺鳞状细胞癌组织中的表达，并探讨其表达与患者临床病理参数之间的关系。 方法收集63例原发性肺鳞状细胞癌手术石蜡切片标本和20例正常肺上皮组织标本，采用免疫组织化学染色技术检测CNTN-1表达，并分析其与患者临床病理参数之间的关系。 结果63例原发性肺鳞癌组织标本中，阳性表达35例，阴性表达26例，2例因石蜡切片上的标本脱落而无癌组织，CNTN-1在人正常肺泡上皮组织中不表达，在原发性肺鳞状细胞癌组织中广泛表达，阳性率为55.56%(35/63)；χ²检验或Fisher精确概率法检验结果显示，CNTN-1阳性表达与患者吸烟和术前淋巴结侵袭显著相关(P<0.05)，而CNTN-1差异表达与患者各临床病理参数之间无相关性。 结论CNTN-1是一个潜在的原发性肺鳞状细胞癌患者预后的生物学标志物。

Expression and clinical significance of contactin-1 in patients with primary lung squamous cell carcinoma

Objective To investigate the expression of contactin-1(CNTN-1)in the patients with primary lung squamous cell carcinoma and to explore the relationship between the CNTN-1 expression and the clinical pathologic parameters.Methods The expression levels of CNTN-1 in the tumor tissues from 63 patients with primary lung squamous cell carcinoma and 20 human samples with normal lung epithelial tissues were analyzed by immunohistochemistry.Results In 63 primary lung squamous cell carcinoma tissue samples,35 cases with positive expression,26 cases with negative expression,2 cases invalid,CNTN-1 expressed in the primary lung squamous cell carcinoma tissues with a positive rate of 55.65%,while it was undetectable in the normal human lung epithelial tissues.Moreover,the positive staining of CNTN-1 was found to be significantly correlated with the smoking history(P<0.05)and the lymphatic invasion before surgery(P<0.05).However,no significant difference was found between the levels of CNTN-1 expression and the clinical pathologic parameters of the patients with primary lung squamous cell carcinoma.Conclusion CNTN-1 might be a potential biomarker to predict the prognosis of the patients with primary lung squamous cell carcinoma.