不同促排卵方案对多囊卵巢综合征不孕症患者治疗效果的临床研究

目的研究不同促排卵方案对多囊卵巢综合征(PCOS)不孕症患者的治疗效果。方法选取我院自2017年1月～2019年1月收治的90例PCOS不孕症患者,按随机数字表法分为两组,每组45例。对照组给予克罗米芬(CC)促排卵方案治疗,观察组给予CC联合来曲唑(LE)促排卵方案治疗,治疗周期中,如无优势卵泡发育、肌注尿促性素(HMG)。比较两组患者的促排卵效果、子宫内膜与卵泡发育情况及妊娠结局。结果观察组的诱排时间短于对照组,HMG用量少于对照组,排卵率高于对照组(P0.05);观察组子宫内膜厚度大于对照组,成熟卵泡个数少于对照组(P0.05),两组最大卵泡直径比较,差异无统计学意义(P0.05);观察组临床妊娠率高于对照组(P0.05),两组流产、多胎妊娠、OHSS发生率比较,差异均无统计学意义(P0.05)。结论相较于CC单独促排卵,CC联合LE促排卵方案治疗PCOS不孕症可明显缩短诱排时间,减少HMG用量,提高排卵率与妊娠率,改善妊娠结局。

Clinical study on the therapeutic effect of different ovulation induction regimens on infertility patients with polycystic ovary syndrome

Objective To study the therapeutic effect of different ovulation induction regimens on infertility patients with polycystic ovary syndrome(PCOS).Methods 90 patients with PCOS infertility admitted to our hospital from January 2017 to January 2019 were divided into two groups according to random number table method,with 45 cases in each group.The control group was treated with clomiphene citrate(CC) ovulation induction therapy,and the observation group was given CC combined with letrozole(LE) ovulation induction therapy.During the treatment cycle,if there was no dominant follicular development,the patients were given intramuscular injection of rinary human menopausal gonadotropin(HMG).The effect of ovulation induction,endometrial and follicular development,and pregnancy outcome were compared between the two groups.Results The induction time of the observation group was shorter than that of the control group.The dose of HMG was lower than that of the control group,and the ovulation rate was higher than that of the control group(P<0.05).The endometrial thickness of the observation group was larger than that of the control group,and the number of mature follicles was less than that of the control group(P<0.05).There was no significant difference in the maximum follicle diameter between the two groups(P>0.05).The clinical pregnancy rate of the observation group was higher than that of the control group (P<0.05).There was no significant difference in the incidence of abortion,mul tiple pregnancy and OHSS between two groups(P>0.05).Conclusion Compared to CC ovulation induction alone,CC combined with LE ovulation induction therapy for PCOS infertility can significantly shorten the time of induction,reduce the dose of HMG,increase the rate of ovulation and pregnancy rate,and improve the pregnancy outcome.