血压变异性与非高血压冠状动脉病变程度相关性研究

目的对非高血压合并冠心病患者的24 h动态血压进行分析,探讨非高血压合并冠心病患者血压变异性与冠状动脉病变程度的相关性。方法选择300例诊断冠心病行冠脉造影的非高血压患者纳入研究,分为非冠心病组和冠心病组,对入选患者进行24 h动态血压监测和冠状动脉造影,观察24 h收缩压变异系数(24 h SBPCV)、白天收缩压变异系数(dSBPCV)、24 h舒张压变异系数(24 h DPBCV)、白天舒张压变异系数(dDBPCV)、夜间收缩压变异系数(nSBPCV)、夜间舒张压变异系数(nDBPCV)。并分析两组血压变异性与冠状动脉病变程度和冠状动脉SSS评分的相关性。结果冠心病组24 h收缩压变异系数(r=0.075)、24 h舒张压变异系数(r=0.090)、夜间收缩压变异系数(r=0.628)、夜间舒张压变异系数(r=0.708)均明显高于非冠心病组,且血压变异性随冠状动脉狭窄支数的增加而增加。患者夜间收缩压变异系数(nSBPCV)、夜间舒张压变异系数(nDBPCV)均与SSS值之间呈正相关(回归系数B分别为0.028,0.033,P0.05)。结论血压变异性与非高血压患者冠状动脉病变程度密切相关,是冠心病的一项重要预测指标。

Correlation between blood pressure variability and degree of non-hypertensive coronary artery disease

Objective To observe and analyze the 24 h ambulatory blood pressure in non-hypertensive patients with coronary heart disease,and to explore the correlation between blood pressure variability and the degree of coronary artery disease in non-hypertensive patients with coronary heart disease.Methods A total of 300 non-hypertensive patients with coronary heart disease who underwent coronary angiography were enrolled.They were divided into noncoronary heart disease group and coronary heart disease group.24 h ambulatory blood pressure monitoring and coronary angiography were performed on the selected patients.24 h systolic blood pressure coefficient of variation(24 h SBPCV),daytime systolic blood pressure coefficient of variation(dSBPCV),24 h diastolic blood pressure coefficient of variation(24 h DPBCV),daytime diastolic blood pressure coefficient of variation(dDBPCV),nocturnal systolic blood pressure coefficient of variation(nSBPCV),and nocturnal diastolic blood pressure coefficient of variation(nDBPCV)was observed.The correlation between blood pressure variability and the degree of coronary artery lesions and coronary SSS scores was analyzed.Results The 24 h systolic blood pressure coefficient of variation(r=0.075),24 h diastolic blood pressure coefficient of variation(r=0.090),nocturnal systolic blood pressure coefficient of variation(r=0.628),and nocturnal diastolic blood pressure variation coefficient(r=0.708)in the coronary heart disease group was higher than that of the noncoronary heart disease group.And the blood pressure variability increased with the increase of number of coronary artery stenosis.The nocturnal systolic blood pressure coefficient of variation(nSBPCV)and nocturnal diastolic blood pressure coefficient of variation(nDBPCV)were positively correlated with SSS values(regression coefficient B was 0.028,0.033,P<0.05).Conclusion Blood pressure variability is closely related to the degree of coronary artery disease in non-hypertensive patients,and it is an important predictor of coronary heart disease.