新生儿窒息后S100B蛋白变化及其与脑损伤的关系

目的探讨外周血S100B蛋白在新生儿窒息中的变化及其与脑损伤的关系。方法采用酶联免疫吸附试验双抗体夹心法动态检测50例窒息新生儿及20例正常新生儿S100B蛋白,并分析其以窒息后脑损伤的关系。结果窒息新生儿急性期外周血S100B蛋白含量明显高于对照组（P〈0.01）,头颅CT显示有脑损伤组S100B蛋白明显高于CT正常组,差异有统计学意义（P〈0.05）;恢复期血S100B蛋白含量较急性期明显下降,与急性期相比具有显著性差异（P〈0.05）。结论窒息新生儿外周血S100B蛋白水平明显增高,血S100B蛋白检测有助于新生儿窒息后脑损伤的判断。

Relation of the variations of S100Bprotein levels and brain damage in neonatal asphyxia

Objective To study the changes of S100Bprotein levels and the relation of brain damage to their in neonatal asphyxia. Methods The concentrations of IL-6 and IGF-1 in peripheral serum were detected in 50 asphyxiated newborn and 20 normal newborns （control group ） by the method of ELISA, And analyse the relation of brain damage to their in neonatal asphyxia. Results The concentration of S100Bprotein in asphyxiated newborn was higher than that of normal newborns in acute phase. The SlOOBprotein in the patients with brain damage displayed by skull-CT were higher than those in the patients without brain damage （ P 〈 0. 05 ）. The level of S100B protein in recovery phase was significantly lower than that in acute phase （P 〈 0.01 ） ; Conclusion the concentration of S100Bprotein in peripheral blood of asphyxiated newborn increase significantly. It might be a valuable index for the diagnosis of neonatal asphyxia following brain damage.