慢性苯中毒对细胞周期及DNA损伤的影响

苯是应用较为广泛的化学物质，可通过皮肤、呼吸道、消化道等进入体内，长期低浓度接触可导致血液系统的损害，如白细胞减少、再生障碍性贫血、骨髓增生异常综合征、白血病等。近年研究发现，细胞周期相关调控蛋白与慢性苯中毒的易感性有关，慢性苯中毒对染色体产生一定的损伤作用，可致接苯工人微核率显著升高。本文就慢性苯中毒对细胞周期的影响及DNA损伤进行概述。

Effects of chronic benzene poisoning on cell cycle and DNA damage

Benzene is a widely used chemical substance, which can enter the body through the skin, respiratory tract, digestive tract, etc. Long term low concentration exposure can cause damage to the blood system, such as leukopenia, aplastic anemia, myelodysplastic syndrome, leukemia, etc. Recent studies have found that cell cycle related regulatory proteins are related to the susceptibility to chronic benzene poisoning. Chronic benzene poisoning has a certain damage effect on chromosomes, which can significantly increase the micronucleus rate of benzene exposed workers. In this paper, the influence of chronic benzene poisoning on cell cycle and DNA damage were summarized.