手术结合放射治疗和单纯喉部分切除术治疗喉癌的临床效果比较

目的 探讨手术结合放射治疗和单纯喉部分切除术治疗喉癌的临床效果及安全性比较。方法 选取2020年1月—2021年1月我院喉癌患者62例,按随机数字表法分为观察组(n=31)与对照组(n=31),对照组采用单纯喉部分切除术。观察组采用手术结合放射治疗。对比两组一般资料、临床效果、5年生存率、并发症发生率、健康状况调查简表(SF-36)评分。结果 两组性别、癌症分期、年龄、病理分型对比差异无统计学意义(P>0.05);观察组总有效率90.32%(28/31)较对照组67.74%(21/31)高(χ2=4.769,P=0.029);观察组5年生存率90.32%(28/31)较对照组67.74%(21/31)高(χ2=4.769,P=0.029);观察组并发症发生率12.90%(4/31)较对照组38.71%(12/31)低(χ2=5.391,P=0.020);术后治疗后,各组躯体疼痛、生理功能、活力评分均较术前高,观察组躯体疼痛(t=4.959,P<0.001)、生理功能(t=12.020,P<0.001)、活力评分(t=12.984,P<0.001)均较对照组高。结论 采用手术结合放射治疗对比单纯喉部分切除术治疗喉癌,可提高临床效果、5年生存率,并具有安全性,可改善生活质量。

Comparison of clinical effects between surgery combined with radiotherapy and partial laryngectomy alone in treatment of laryngeal cancer

Objective To evaluate and compare the clinical effects and safeties between surgery combined with radiotherapy and partial laryngectomy alone in the treatment of laryngeal cancer. Methods A total of 62 patients with laryngeal cancer in our hospital from January 2020 to January 2021 were randomly divided into an observation group (n=31) and a control group (n=31). The control group was treated with simple partial laryngectomy, and the observation group was treated with surgery combined with radiotherapy. The general data, clinical effects, 5-year survival rates, complication rates and SF-36 scores of the two groups were compared. Results There were no significant differences in gender, cancer stage, age and pathological classification between the two groups (P>0.05). The total effective rate of the observation group was 90.32% (28/31), higher than that of the control group (67.74% (21/31) (χ2=4.769, P=0.029). The 5-year survival rate of the observation group was 90.32% (28/31), higher than that of the control group (67.74% (21/31) (χ2=4.769, P=0.029). The incidence of complications in the observation group was 12.90% (4/31), lower than that (38.71%, 12/31) in the control group (χ2=5.391, P=0.020). After postoperative treatment, the scores of physical pain, physiological function, and vitality in each group were higher than those before the operation. The scores of physical pain (t=4.959, P<0.001), physiological function (t=12.020, P<0.001), and vitality (t=12.984, P<0.001) in the observation group were significantly higher than those in the control group. Conclusion Compared with partial laryngectomy alone, surgery combined with radiotherapy can improve the clinical effect, 5-year survival rate, safety and quality of life.