SLE病人外周血sCD28、sCD137水平及临床意义

目的探讨SLE病人血清可溶性T细胞共刺激分子sCD28、sCD137的水平及其与SLE病情活动的相关性。方法收集不同活动度的SLE病人及健康对照者外周血，分离血清，采用BA-ELISA法定量检测受试者外周血中sCD28、sCD137含量，分析比较其含量变化与SLE疾病活动度及相关实验室指标的相关性。结果SLE病人组血清sCD28和sCD137水平均显著高于健康对照组(P < 0.01)；中度活动组血清sCD28水平和sCD137水平显著高于轻度活动组；重度活动组血清sCD28水平和sCD137水平显著高于中度活动组(P < 0.01)；SLE病人血清sCD28、sCD137水平与病人SLEDAI评分、抗核抗体水平呈正相关，与C3水平呈负相关(P < 0.01)。结论SLE病人血清sCD28和sCD137水平显著升高且与其疾病活动度呈正相关，有望成为判断SLE病情活动度的参考指标之一。

Levels and clinical significance of sCD28 and sCD137 in peripheral blood of SLE patients

ObjectiveTo investigate the correlation of the serum levels of sCD28 and sCD137 in systemic lupus erythematosus(SLE) and its significance.MethodsThe serum sCD28 and sCD137 in 54 patients with SLE and in healthy control were detected by BA-ELISA.The correlation of the serum levels of sCD28 and sCD137 with the SLE patients'disease activity index(SLEDAI) score and laboratory findings were analyzed.ResultsThe levels of serum sCD28 and sCD137 in SLE were significantly higher than those in healthy control group(P < 0.01).The levels of serum sCD28 and sCD137 in active SLE were significantly higher than those in remission(P < 0.01).The levels of serum sCD28 and sCD137 in SLE were positively correlated with SLEDAI score and antinuclear antibaby, but were negatively correlated with complement C3(P < 0.01).ConclusionsThere was positive correlation between the levels of serum sCD28 and sCD137 in SLE and its diseases activity index, which is expected to be one of the reference indexes to judge SLE disease activity.