持续皮下胰岛素输注治疗妊娠期糖尿病的效果观察

目的 分析持续皮下胰岛素输注对妊娠期糖尿病(GDM)患者血糖水平及妊娠结局的影响.方法 以2018年8月—2019年8月本院收治的GDM患者120例为研究对象,采用随机数字表法将其分为对照组和治疗组,各60例,对照组给予常规胰岛素皮下注射治疗,治疗组给予持续皮下胰岛素输注.比较两组患者治疗前后空腹血糖(FBG)、糖化血...

Effect of continuous subcutaneous insulin infusion on gestational diabetes mellitus

Objective To evaluate the effect of continuous subcutaneous insulin infusion on the blood glucose level and pregnancy outcome in patients with gestational diabetes mellitus (GDM). Methods A total of 120 patients with GDM treated in our hospital from August 2018 to August 2019 were randomly divided into a control group and a treatment group, with 60 cases in each group. The control group was treated with the routine insulin subcutaneous injection, and the treatment group was treated with the continuous subcutaneous insulin infusion. The levels of fasting blood glucose (FBG), glycosylated hemoglobin A1c (HbA1c) and 2-h postprandial blood glucose (2hPBG) before and after treatment, the incidence of hypoglycemia, insulin dosage, blood glucose standard time and adverse pregnancy outcomes were investigated and compared between the two groups. Results There was no significant difference in the levels of FBG, HbA1c and 2hPBG between the two groups before treatment (P>0.05). After treatment, the average levels of FBG, HbA1c and 2hPBG were respectively in the treatment group, which were lower than those before treatment: (9.34±2.19) mmol/L, (6.87±0.65)%, and (11.97±3.08) mmol/L respectively in the control group, and (9.38±2.13) mmol/L, (6.91±0.66)%, and (12.01±3.07) mmol/L respectively in the treatment group (all P<0.05). The incidence of hypoglycemia in the treatment group was 1.67%, lower than 11.67% in the control group (χ2=4.821, P=0.028). The time of reaching the standard of blood glucose in the treatment group was (4.18±0.39) d, which was shorter than (5.27±0.53) d in the control group (χ2=12.831, P<0.001). After treatment, the incidence of adverse pregnancy outcomes in the treatment group was 10.00%, lower than 25.00% in the control group (χ2=4.675, P=0.031). Conclusion The continuous subcutaneous insulin infusion in the patients with GDM is conducive to better control blood glucose level, improve pregnancy outcome and reduce the incidence of adverse pregnancy outcome.