治疗性乙型肝炎疫苗研究进展

全球范围内有超过4亿慢性乙型肝炎病毒携带者,这些患者发展为肝硬化和肝癌的危险性较大.现有疗法不能长期控制大多数患者的病毒复制,而治疗性乙型肝炎疫苗因其独特的优点正成为新的研究热点.此文就治疗性乙型肝炎疫苗的分类及最新研究进展加以综述.

Research advances in therapeutic vaccination against hepatitis B virus

Michel ML.Davis HL.Schleef M DNA-mediated immunization to the hepatitis B surface antigen in mice:aspects of the humoral response mimic hepatitis B viral infection in humans 1995(12)

Davis HL.Michel ML.Whalen RG DNA-based immunization induces continuous secretion of hepatitis B surface antigen and high level of circulating antibody 1993(2)

Mancini M.Hadchouel M.Davis HL DNA-mediated immunization in a transgenic mouse model of the hepatitis B surface antigen chronic carrier state 1996(22)

Pancholi P.Lee DH.Perkus M DNA prime/canarypox boost-based immunotherapy of chronic hepatitis B virus infectionin a chimpanzee 2001(2)

Shata MT.Pfahler W.Brotman B Attempted therapeutic immunization in a chimpanzee chronic HBV carrier with a high viral load 2006(3)

Tacket CO.Roy MJ.Widera G Phage 1 safety and immune response studies of a DNA vaccine enconding hepatitis B virus surface antigen delivered by a gene delivery device 1999(22)

Roy MJ.Wu MS.Barr LJ Induction of antigen specific CD8+ T cells,T helper cells,and protective levels of antibody in humans by particle-mediated administration of a hepatitis B virus DNA vaccine 2001(7/8)

Mancini-Bourgine M.Fontaine H.Scott-Algara D Induction or expansion of T-cell responses by a hepatitis B DNA vaccine administered to chronic HBV carriers 2004(4)

Riedl P.Wieland A.Lamberth K Elimination of immu-nodominant epitopes from multispecific DNA-based vaccines allows induction of CD8 T cells that have a striking antiviral potential 2009(1)

Banchereau J.Steinman RM Dendritic cells and the control of immunity 1998(6673)

Wang FS.Xing LH.Liu MX Dysfunction of peripheral blood dendritic cells from patients with chronic hepatitis B virus infection 2001(4)

Arima S.Akbar SM.Michitaka K Impaired function of antigen-presenting dendritic cells in patients with chronic hepatitis B:localization of HBV DNA and HBV RNA in blood DC by in situ hybridization 2003(2)

Beckebaum S.Cicinnati VR.Zhang X Hepatitis B virus induced defect of monocyte-derived dendritic cells leads to impaired T helper type 1 response in vitro:mechanisms for viral immune escape 2003(4)

van der Molen RG.Sprengers D.Binda RS Functional impairment of myeloid and plasmacytoid dendritic cells of patients with chronic hepatitis B 2004(3)

Akbar SM.Furukawa S.Hasebe A Production and efficacy of a dendritic cell-based therapeutic vaccine for murine chronic hepatitis B virus carrier 2004(2)

Fazle Akbar SM.Furukawa S.Onji M Safety and efficacy of hepatitis B surface antigen-pulsed dendritic cells in human volunteers 2004(3)

Chen M.Li YG.Zhang DZ Therapeutic effect of autolo-gous dendritic cell vaccine on patients with chronic hepatitis B:a clinical study 2005(12)

Hemmi H.Takeuchi O.Kawai T A Toll-like receptor recognizes bacterial DNA 2000(6813)

Li N.Fan XG.Chen ZH Inhibition of the hepatitis B virus replication in vitro by an oligodeoxynucleotide containing cytidine-guanosine motifs 2006(1)

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