Steroid‐responsive,progressive, focal measles virus brain infection |
| |
| Authors: | Israel Steiner MD Vered Livneh MD Chen Hoffmann MD Dvora Nass MD Orna Mor PhD Joab Chapman MD PhD |
| |
| Affiliation: | 1. Department of Neurology, Rabin Medical Center, Petach Tikva, Israel;2. Departments of Neurology, Sheba Medical Center, Tel Hashomer, affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv;3. Departments of Radiology, Sheba Medical Center, Tel Hashomer, affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv;4. Department of Pathology, Sheba Medical Center, Tel Hashomer, affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv;5. National HIV Reference Laboratory at the Ministry of Health, Sheba Medical Center, Tel Hashomer, Israel |
| |
| Abstract: | Chronic measles virus infection of the brain causes subacute sclerosing panencephalitis (SSPE), a progressive, relentless fatal disorder. We report a 52‐year‐old male who developed focal, chronic persistent measles virus infection of the brain following interferon and ribavirin therapy for hepatitis C, and who responded to steroid therapy. This case, diametrically different from SSPE, has 2 unique features, its focal nature and its permissive response to steroids, that may add to the understanding of the pathogenesis of SSPE and the mechanism enabling viruses to evade the immune response and establish persistent brain infection. Ann Neurol 2014;75:967–970 |
| |
| Keywords: | |
|
|
