Enhanced production of nitric oxide in rat organs in heat shock |
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| Authors: | E. B. Manukhina I. Yu. Malyshev V. D. Mikoyan L. N. Kubrina A. F. Vanin |
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| Affiliation: | (1) Laboratory of Membrane Mechanisms of Adaptation, Moscow;(2) Laboratory of Genetic Mechanisms of Adaptation, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow;(3) Laboratory of Biopolymer Physical Chemistry, Institute of Chemical Physics, Russian Academy of Sciences, Moscow |
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| Abstract: | ![]()
Heat shock is shown to lend a marked boost to the production of nitric oxide (NO), which attains the maximal level 1 hour after exposure and returns to the initial level after 24 hours. The generation of NO in all studied organs is completely blocked by Nω-nitro-L-arginine, an inhibitor of NO synthase, both in the control and after hyperthermia. Thus, heat shock markedly stimulates NO synthesis. This generalized effect may underlie the drop in the peripheral vascular tone that is characteristic of heat shock. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, No. 5, pp. 520–523, May, 1996 |
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| Keywords: | nitric oxide heat shock electron paramagnetic resonance inhibitor of NO synthase |
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