Tinospora cordifolia extract modulates COX-2, iNOS,ICAM-1, pro-inflammatory cytokines and redox status in murine model of asthma |
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| Authors: | M. Tiwari U.N. Dwivedi P. Kakkar |
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| Affiliation: | 1. Herbal Research Section, Food Drug & Chemical Toxicology Division, CSIR – Indian Institute of Toxicology Research, P.O. Box 80, M.G. Marg, Lucknow 226001, Uttar Pradesh, India;2. Department of Biochemistry, University of Lucknow, Lucknow 226007, Uttar Pradesh, India |
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| Abstract: | ![]()
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| Keywords: | ABTS, 2,2?-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) ALT, alanine transaminase AST, aspartate transaminase BALF, bronchoalveolar lavage fluid BHT, butylated hydroxytoluene BSA, bovine serum albumin CMC, carboxymethylcellulose COX-2, cyclooxygenase-2 DDW, double distilled water DEX, dexamethasone DNA, deoxyribonucleic acid DNPH, 2,4-dinitrophenylhydrazine DTNB, 5,5?-dithiobis-(2-nitrobenzoic acid) DTT, dithiothreitol EDTA, ethylenediaminetetraacetic acid EGTA, ethylene glycol tetraacetic acid ELISA, enzyme linked immunosorbent assay EPO, eosinophil peroxidase GPx, glutathione peroxidase GR, glutathione reductase GSH, glutathione reduced GSSG, glutathione oxidized HEPES, 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid H2O2, hydrogen peroxide ICAM-1, intercellular adhesion molecule 1 IFN, interferon IgE, immunoglobulin E IκB, inhibitor of kappa B IL, interleukin iNOS, inducible nitric oxide synthase JNK, c-Jun N-terminal kinase KCl, potassium chloride MAPK, mitogen activated protein kinase MDA, malondialdehyde MPO, myeloperoxidase NADH, nicotinamide adenine dinucleotide NADPH, nicotinamide adenine dinucleotide phosphate NADPH oxidase, nicotinamide adenine dinucleotide phosphate-oxidase NBT, nitroblue tetrazolium NFκB, nuclear factor kappa B NO, nitric oxide Ova, Ovalbumin PAS, periodic acid Schiff stain PBS, phosphate buffered saline PBST, phosphate buffered saline Tween 20 PGE2, prostaglandin E2 PMNs, polymorphonuclear leukocytes PMS, phenazine methosulphate PVDF, polyvinylidene fluoride PMSF, phenylmethylsulfonyl fluoride RANTES, regulated on activation normal T cell expressed and secreted ROS, reactive oxygen species RP HPLC, reverse phase high performance liquid chromatography SDS, sodium dodecyl sulfate SOD, superoxide dismutase sRaw, specific airway resistance Th, T helper TBA, thiobarbituric acid TBARS, thiobarbituric acid reactive substances TCA, trichloroacetic acid t-BHP, tert-butyl hydroperoxide Tc, Tinospora cordifolia (Willd.) Miers. TEAC, trolox equivalent antioxidant capacity TNF, tumor necrosis factor VCAM-1, vascular cell adhesion molecule 1 |
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