Effect of nigranoic acid on Ca influx and its downstream signal mechanism in NGF-differentiated PC12 cells |
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| Authors: | Xiao-Xi Yuan Li-Ping Yang Zhong-Lin Yang Wei-Lie Xiao Han-Dong Sun Gui-Sheng Wu Huai-Rong Luo |
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| Affiliation: | 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, China;2. University of Chinese Academy of Sciences, Beijing 100039, China;3. Yunnan Institute of Traditional Chinese Medicine and Materia Medica, Kunming 650223, Yunnan, China |
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| Abstract: | |
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| Keywords: | SBB1, nigranoic acid AD, Alzheimer?s disease PD, Parkinson?s disease LTP, long-term potentiation NO, nitric oxide NOS, NO synthase ERK1/2, extracellular signal regulated kinase 1 and 2 CaMKII, calcium/calmodulin-dependent protein kinase II BDNF, brain-derived neurotrophic factor MAPK, mitogen-activated protein kinase CREB, cyclic AMP-response element binging protein NGF, nerve growth factor [Ca2+]i, intracellular Ca2+ concentration Schisandra chinensis, Schisandra chinensis CNS, central nervous system MTT, 3-(4,5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide DMSO, dimethyl sulfoxide SDS, sodium dodecyl sulfate EGTA, ethylene glycol-bis (2-aminoethylether)-N,N,N&prime ,N&prime -tetraacetic acid BAPTA-AM, 1,2-bis(2-amino-5-fluorophenoxy) ethane-N,N,N2,N2-tetraacetic acid tetrakis (acetoxymethyl) ester l-NAME, Nω-nitro-l-arginine methyl ester hydrochloride KN-62, 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-l-tyrosyl]-4-phenylpiperazine |
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