Ethnic specificity of variants of the ESR1, HK3, BRSK1 genes and the 8q22.3 locus: No association with premature ovarian failure (POF) in Serbian women |
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Authors: | Yingying Qin Svetlana Vujovic Guangyu Li Jin Li Raymond Dalgleish Joe Leigh Simpson Maja Ivanisevic Miomira Ivovic Milina Tancic Farook Al-Azzawi Zi-Jiang Chen |
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Affiliation: | 1. Center for Reproductive Medicine, Shandong Provincial Hospital, Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, The Key Laboratory for Reproductive Endocrinology of Ministry of Education, Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, China;2. Faculty of Medicine, University of Belgrade, Clinic of Endocrinology, Clinical Center of Serbia, Belgrade, Serbia;3. Gynaecology Research Unit, University Hospitals of Leicester, United Kingdom;4. Department of Genetics, University of Leicester, Leicester, United Kingdom;5. Research and Global Programs March of Dimes Foundation, White Plains, NY, USA;6. Human & Molecular Genetics, Obstetrics and Gynecology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA;g Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China |
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Abstract: | ObjectiveTo identify whether variants found in a large Han Chinese cohort – 8q22.3 SNPs rs3847153 and rs3108910; and one SNP each in HK3 (rs2278493), ESR1 (rs2234693) and BRSK1 (rs12611091) – are associated with premature ovarian failure (POF) in a different ethnic group (Serbian).DesignCase–control genetic association study in 197 Serbian POF cases and 552 matched controls.ResultsNone of the SNPs found associated with POF in Chinese cohort were found to be associated in the Serbian sample.ConclusionsIn contrast to Han Chinese, no association was found between POF in Serbian women and any of the four tested loci: 8q22.3, HK3, ESR1 and BRSK1. This indicates that ethnically distinct populations may show differences in gene-regulating pathways and genes causing POF. |
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Keywords: | BRSK1 ESR1 HK3 Premature ovarian failure (POF) 8q22.3 |
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