沙美特罗替卡松粉吸入剂联合汉防己甲素治疗尘肺的临床观察 |
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引用本文: | 尹琴,;张继先,;谢姣,;伏振,;余贻汉.沙美特罗替卡松粉吸入剂联合汉防己甲素治疗尘肺的临床观察[J].中国药房,2014(44):4144-4146. |
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作者姓名: | 尹琴 ;张继先 ;谢姣 ;伏振 ;余贻汉 |
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作者单位: | [1]湖北省新华医院呼吸内科,武汉430015; [2]湖北省新华医院中毒与职业病科,武汉430015 |
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基金项目: | 国家临床重点专科建设项目 |
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摘 要: | 目的:观察沙美特罗替卡松粉吸入剂联合汉防己甲素治疗尘肺的临床疗效和安全性。方法:将67例尘肺男性患者随机分为对照组(35例)和观察组(32例)。两组患者均给予抗感染、化痰、平喘、营养支持等常规治疗。与此同时,对照组患者给予沙美特罗替卡松粉吸入剂(每吸含沙美特罗50μg、丙酸氟替卡松250μg)每日2吸;观察组患者在对照组治疗的基础上给予汉防己甲素80 mg,口服,每日3次,连用6 d后停用1 d。两组患者疗程均为3个月。观察两组患者临床疗效,治疗前后临床症状总评分、1秒用力呼气容积(FEV1)、用力肺活量(FVC)、FEV1/FVC及不良反应发生情况。结果:观察组患者总有效率显著高于对照组,两组比较差异有统计学意义(P<0.05)。治疗前两组患者临床症状总评分、FEV1、FVC、FEV1/FVC比较,差异均无统计学意义(P>0.05);治疗后两组患者临床症状总评分均显著低于同组治疗前,且观察组低于对照组,而FEV1、FVC、FEV1/FVC均显著高于同组治疗前,且观察组高于对照组,差异均有统计学意义(P<0.05)。两组患者治疗期间均未见明显不良反应发生。结论:沙美特罗替卡松粉吸入剂联合汉防己甲素治疗尘肺较单用沙美特罗替卡松粉吸入剂疗效更显著,安全性相似。
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关 键 词: | 沙美特罗替卡松粉吸入剂 汉防己甲素 尘肺 疗效 安全性 |
Clinical Observation of Seretide Inhalation Combined with Tetrandrine in the Treatment of Pneumoconiosis |
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Institution: | YIN Qin, ZHANG Ji-xian, XIE Jiao, FU Zhen, YU Yi-han( 1.Dept. of Respiratory Medicine, Hubei Xinhua Hospital, Wuhan 430015, China; 2.Dept. of Poisoning and Occupational Disease, Hubei Xinhua Hospital, Wu- han 430015, China) |
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Abstract: | OBJECTIVE:To observe clinical efficacy and safety of Seretide inhalation combined with tetrandrine in the treatment of pneumoconiosis. METHODS:67 pneumoconiosis patients were randomly divided into control group(35 cases)and observation group(32 cases). Both groups received routine symptomatic treatment of anti-infection,reducing phlegm,relieving asthma and nutritional support. Control group was additionally given Seretide inhalation(containing seretide 50 μg and fluticasone propionate 250 μg per inhalation time)twice a day. Observation group was additionally treated with tetrandrine 80 orally 3 times a day for consecutive 6 days,drug withdrawal for one day on the basis of control group. Treatment course of 2 groups lasted for 3 months.Clinical efficacies of 2 groups were observed. Total clinical symptom score,FEV1,FEV1/FVC%,FVC and the occurrence of ADR were observed before and after treatment. RESULTS:Total effective rate of observation group was significantly higher than that of control group;there was statistical significance(P〈0.05). There was no statistical significance in total clinical symptom score between 2 groups before treatment(P〉0.05). Total clinical symptom score of 2 groups after treatment was significantly lower than before;the observation group was lower than the control group;there was statistical significance(P〈0.05). No obvious ADR was found in 2 groups during treatment. CONCLUSIONS:Seretide inhalation combined with tetrandrine in more effective and safer than Seretide inhalation alone in the treatment of pneumoconiosis. |
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Keywords: | Seretide inhalation Tetrandrine Pneumoconiosis Therapeutic eifficacy Safety |
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