盐酸伐昔洛韦联合复方甘草酸苷治疗玫瑰糠疹的临床观察

目的:观察盐酸伐昔洛韦联合复方甘草酸苷治疗玫瑰糠疹的临床疗效和安全性。方法:将107例玫瑰糠疹患者随机分为对照组(志愿者,n=37)、观察组(n=35)和研究组(n=35)。对照组患者不给予用药治疗,等待自愈;观察组患者给予复方甘草酸苷3片,口服,每日3次;研究组患者在观察组治疗的基础上给予盐酸伐昔洛韦250 mg,口服,每日3次。3组患者均观察2周。观察3组患者未用药或用药1周、2周后疗效,并记录不良反应发生情况。结果:治疗1周后,研究组患者总有效率>观察组>对照组,3组比较差异有统计学意义(P<0.05);治疗2周后,研究组与观察组患者总有效率均显著高于对照组,差异均有统计学意义(P<0.05),但研究组与观察组比较差异无统计学意义(P>0.05)。3组患者观察期间均未见明显不良反应发生。结论:盐酸伐昔洛韦联合复方甘草酸苷治疗玫瑰糠疹较单用复方甘草酸苷或未用药物疗效较好、起效较快,安全性相似。

Clinical Observation of Valaciclovir Hydrochloride Combined with Compound Glycyrrhizin in the Treatment of Pityriasis Rosea

OBJECTIVE：To observe the clinical efficacy and safety of valaciclovir hydrochloride combined with compound glycyrrhizin in the treatment of pityriasis rosea. METHODS：107 patients with pityriasis rosea were randomly divided into control group（volunteer,n=37）,observation group（n=35）and study group（n=35）. Control group didn’t received any drug and waited for self-healing;observation group was given Compound glycyrrhizin,3 tablets,orally,3 times a day;study group was additionally given valaciclovir hydrochloride 250 mg orally three times a day on the basis of observation group. 3 groups were observed for 2 weeks. Therapeutic efficacies of 3 groups were evaluated after no treatment one week and two weeks of treatment,and the occurrence of ADR were recorded. RESULTS：After one week of treatment,total effective rate was in descending order：study group〉observation group〉control group;there was statistical significance（P〈0.05）. After two week of treatment,total effective rate of study group and observation group were significantly higher than that of control group;there was statistical significance（P〈0.05）. There was no statistical significance between study group and observation group（P〉0.05）. No obvious ADR was found in3 groups during observation. CONCLUSIONS：Valaciclovir hydrochloride combined with compound glycyrrhizin is more effective than compound glycyrrhizin alone or no drug treatment in the treatment of pityriasis rosea with similar safety.